CENTRAL AND PERIPHERAL MINOCYCLINE SUPPRESSES MOTOR-ACTIVITY IN RATS
CENTRAL AND PERIPHERAL MINOCYCLINE SUPPRESSES MOTOR-ACTIVITY IN RATS
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DOI：
10.1016/0091-3057(93)90481-8
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发表时间：
1993-02-01
影响因子：
3.6
通讯作者：
FUCHS, I
中科院分区：
文献类型：
--
作者：
KOFMAN, O;VANEMBDEN, S;FUCHS, I
二甲胺四环素（Minocycline， MIN） HCl是一种四环素衍生物，先前在体外被证明可以抑制激动剂诱导的环磷酸腺苷（cAMP）的积累，并在SC注射后抑制大鼠的运动活性和安非他明诱导的多动症。本研究检测了静脉注射和脑内MIN对基线活动和安非他明诱导的多动的影响。静脉MIN在100和150 mg/kg剂量下抑制两种类型的活性。当注射ICV时，MIN（50杯/2毫升）抑制了安非他明引起的饲养增加，但不影响基线活性。MIN没有减弱cAMP磷酸二酯酶抑制剂罗利普兰引起的行为抑制。MIN对大鼠运动活动具有明显的中枢介导作用；然而，还不可能将MIN的行为效应与其抑制激动剂诱导的cAMP刺激的能力联系起来。
Minocycline (MIN) HCl is a tetracycline derivative previously shown to inhibit agonist-induced accumulation of cyclic adenosine monophosphate (cAMP) in vitro and suppress motor activity and amphetamine-induced hyperactivity in rats following SC injection. The present study examined the effect of IV and intracerebral MIN on baseline activity and amphetamine-induced hyperactivity. IV MIN suppressed both types of activity in doses of 100 and 150 mg/kg. When injected ICV, MIN (50 mug/2 mul) suppressed the increase in rearing elicited by amphetamine but did not affect baseline activity. MIN did not attenuate the behavioral suppression induced by the cAMP phosphodiesterase inhibitor rolipram. MIN apparently has centrally mediated effects on motor activity in rats; however, it is not yet possible to associate MIN's behavioral effects with its ability to inhibit agonist-induced stimulation of cAMP.