Autoantibodies in chronic ITP.
Autoantibodies in chronic ITP.
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慢性 ITP 中的自身抗体。
DOI：
10.1007/bf00320247
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
McMillan,R
中科院分区：
文献类型：
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作者：
Tani,P;Berchtold,P;McMillan,R
慢性ITP是一种破坏性血小板减少综合征，在大多数情况下，由于抗血小板自身抗体。在目前的研究中，我们研究了74例慢性ITP患者使用一种新的免疫珠测定。其中，59例（79.7%）具有可证实的血小板相关自身抗体：48例针对血小板糖蛋白IIb/IIIa，11例针对糖蛋白Ib/IX。对所有患者的血浆自身抗体进行了研究，32例（43.2%）结果呈阳性;在每例患者中，也有针对相同抗原的血小板相关自身抗体。我们的结论是，大多数慢性ITP患者都存在抗血小板膜糖蛋白的自身抗体，免疫珠试验是一种灵敏且可重复的检测方法，适用于医院常规实验室。
Chronic ITP is a syndrome of destructive thrombocytopenia due in most cases to antiplatelet autoantibodies. In the present studies we have studied 74 patients with chronic ITP using a new immunobead assay. Of these, 59 (79.7%) had demonstrable platelet-associated autoantibodies: 48 against platelet glycoprotein IIb/IIIa and 11 against glycoprotein Ib/IX. Plasma autoantibodies were studied in all patients and 32 (43.2%) had positive results; in each case the patient also had platelet-associated autoantibodies directed to the same antigen. We conclude that the majority of patients with chronic ITP have autoantibodies against platelet membrane glycoproteins and that the immunobead assay is a sensitive and reproducible method for their detection which is applicable to the routine hospital laboratory.