Hemodynamic, renal, and endocrine actions of ANF in sheep: effect of 24-h, low-dose infusions.
Hemodynamic, renal, and endocrine actions of ANF in sheep: effect of 24-h, low-dose infusions.
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ANF 对绵羊的血流动力学、肾脏和内分泌作用：24 小时低剂量输注的效果。
DOI：
10.1152/ajpregu.1990.258.5.r1279
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
A. Richards
中科院分区：
文献类型：
--
作者：
C. Charles;E. Espiner;V. Cameron;A. Richards
心钠素(ANF)的少量增加对血流动力学、肾脏和激素功能的综合和持续影响仍不清楚。因此，我们研究了24小时，低剂量(2.4pmol.kg-1.min-1)的大鼠Ile-ANF或单纯赋形剂(对照组)对6只接受恒定钠摄入量的正常绵羊的序贯效应。与对照组相比，静脉注射ANF后血浆ANF升高3倍，血浆鸟苷3‘，5’-环一磷酸持续升高两倍。动脉收缩压和右房压迅速下降，并在ANF输注期间保持显着下降。这些变化与血浆容量持续下降有关，但肾素-血管紧张素-醛固酮系统没有激活。与其他作用不同的是，ANF诱导的钠尿在输注的前8小时是显著的，但不是持续的。这些研究表明，即使在接近正常血浆心钠素浓度的情况下，血液动力学因素，特别是血浆容量的下降，在决定肾脏反应方面也具有重要的生物学效应。
The integrative and sustained effects of small increments in atrial natriuretic factor (ANF) on hemodynamic, renal, and hormonal function are still unclear. Accordingly, we have studied the sequential effects of 24-h, low-dose infusion (2.4 pmol.kg-1.min-1) of rat Ile-ANF or vehicle alone (control) in six normal sheep receiving a constant sodium intake. Compared with control observations, ANF infusions induced a threefold rise in venous plasma ANF and a sustained twofold rise in plasma guanosine 3',5'-cyclic monophosphate. Systolic arterial and right atrial pressures fell promptly and remained significantly reduced for the duration of the ANF infusions. These changes were associated with a sustained fall in plasma volume but no activation of renin-angiotensin-aldosterone system. In contrast to the other actions, ANF-induced natriuresis, which was significant in the first 8 h of infusion, was not sustained. These studies show that significant biological effects occur in response to small ANF increments (20-25 pmol/l) and indicate that hemodynamic factors, especially fall in plasma volume, are important in determining the renal response even at near-normal plasma ANF concentrations.