Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand.
Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand.
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新西兰正常受试者以及患有和未患有癌症的手术患者的血硒和谷胱甘肽过氧化物酶活性。
DOI：
10.1093/ajcn/32.7.1477
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
A. V. Van rij
中科院分区：
文献类型：
--
作者：
M. F. Robinson;P. J. Godfrey;C. Thomson;H. Rea;A. V. Van rij
这项研究是在南岛的奥塔戈进行的，那里的大部分耕地的土壤硒含量很低(低于0.5微克/克)，那里的牲畜中硒(Se)敏感型疾病很常见。测定了104例健康奥塔哥居民、80例癌症患者和66例非肿瘤手术患者的全血、红细胞和血浆中的硒浓度及全血谷胱甘肽过氧化物酶活性(EC1.11.1.9)。60岁以上老年居民血硒水平(0.047+/-0.010微克/毫升血)低于中青年(0.060+/-0.012微克/毫升血)。癌症患者的血硒水平并不低于老年受试者和非癌症患者，不到美国可比水平的一半。两名癌症患者的血Se水平下降，其中五名癌症患者和两名非癌症患者在长期空腹后血硒水平最低(<0.03微克Se/ml血)；这与接受肠外营养且摄入量可忽略不计的患者的值相似。较低的血硒水平与较低的血清白蛋白和酶活性有关。提示癌症患者的低硒状态更可能是疾病的结果，而不是癌症的原因。
This study was carried out in Otago, South Island, where most arable land has a low soil selenium content (less than 0.5 microgram/g) and where selenium (Se) responsive diseases in livestock are common. Se concentration in whole blood, erythrocytes and plasma, and activity of glutathione peroxidase (EC 1.11.1.9) were measured in blood from 104 healthy Otago residents, 80 patients with cancer and 66 noncancer surgical patients. The older residents over 60 years had lower blood Se levels (0.047 +/- 0.010 microgram Se/ml blood) than the young and middle-aged (0.060 +/- 0.012 microgram Se/ml). Blood Se levels of cancer patients were no lower than those of elderly subjects and patients without cancer, and were less than half comparable United States values. Blood Se levels were decreasing in two cancer patients, and the lowest values (less than 0.03 microgram Se/ml blood) were obtained for five cancer patients, and two noncancer patients after a long period of inanition; these were similar to values for patients on parenteral nutrition with negligible intakes. Lower blood Se levels were associated with lower serum albumin and enzyme activities. It is suggested that low Se status of cancer patients was more likely a consequence of their illness than the cause of the cancer.