25-Hydroxyvitamin D Status and Change in Physical Performance and Strength in Older Adults
25-Hydroxyvitamin D Status and Change in Physical Performance and Strength in Older Adults
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DOI：
10.1093/aje/kws147
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发表时间：
2012-12-01
影响因子：
5
通讯作者：
Kritchevsky, Stephen B.
中科院分区：
文献类型：
--
作者：
Houston, Denise K.;Tooze, Janet A.;Kritchevsky, Stephen B.
低25-羟基维生素D（25（OH）D）浓度在老年人中很常见，与身体表现和力量较差有关，但纵向研究的结果并不一致。在健康、衰老和身体成分研究（n 2，641）中，确定了身体机能和力量的25（OH）D阈值，并检查了25（OH）D与身体机能和力量之间的横截面和纵向关联。在1998 - 1999年测量了基线血清25（OH）D，并在基线和2年和4年随访时测量了体能和力量。分段回归模型用于确定25（OH）D阈值。线性回归和混合模型被用来检查横截面和纵向协会。25（OH）D阈值为7080 nmol/L和5570 nmol/L。25（OH）D <50 nmol/L的受试者在基线时以及2年和4年随访时的体能比25（OH）D <75 nmol/L的受试者差（P <0.01）。尽管在4年随访期间体能和力量下降（P 0.0001），但一般而言，下降率与基线25（OH）D无关。在4年的随访中，25（OH）D浓度低的老年人的身体表现较差，但25（OH）D浓度低与身体表现或力量下降速度较快无关。
Low 25-hydroxyvitamin D (25(OH)D) concentrations are common among older adults and are associated with poorer physical performance and strength, but results from longitudinal studies have been inconsistent. The 25(OH)D threshold for physical performance and strength was determined, and both cross-sectional and longitudinal associations between 25(OH)D and physical performance and strength were examined, in men and women aged 7180 years from the Health, Aging, and Body Composition Study (n 2,641). Baseline serum 25(OH)D was measured in 19981999, and physical performance and strength were measured at baseline and at 2- and 4-year follow-up. Piecewise regression models were used to determine 25(OH)D thresholds. Linear regression and mixed models were used to examine cross-sectional and longitudinal associations. The 25(OH)D thresholds were 7080 nmol/L for physical performance and 5570 nmol/L for strength. Participants with 25(OH)D 50 nmol/L had poorer physical performance at baseline and at 2- and 4-year follow-up than participants with 25(OH)D epsilon 75 nmol/L (P 0.01). Although physical performance and strength declined over 4 years of follow-up (P 0.0001), in general, the rate of decline was not associated with baseline 25(OH)D. Older adults with low 25(OH)D concentrations had poorer physical performance over 4 years of follow-up, but low 25(OH)D concentrations were not associated with a faster rate of decline in physical performance or strength.