Aging-related changes in processing of non-target and target stimuli during an auditory oddball task
Aging-related changes in processing of non-target and target stimuli during an auditory oddball task
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DOI：
10.1016/s0301-0511(98)00040-4
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发表时间：
1998-08-01
影响因子：
2.6
通讯作者：
Diaz, F
中科院分区：
文献类型：
--
作者：
Amenedo, E;Diaz, F
共有73名年龄在20-86岁之间的健康受试者进行了听觉“oddball”任务。在20个电极上研究了由非靶刺激引起的N1和P2、由靶刺激引起的N2和P3以及N2 a和N2 b分量（靶减非靶差异波）的年龄依赖性，以检测在任务期间这些刺激的心理生理处理中的任何与年龄相关的变化。年龄相关的非目标ERP的任务内变化的差异也进行了研究。在非靶事件相关电位中，随着年龄的增长，Fz点的P2波幅呈线性增加，任务内变化分析表明，在Pt点，年轻被试的P2波幅在任务过程中降低，而在中年和老年被试中保持不变。这些结果表明存在与年龄相关的抑制缺陷，可能会阻碍注意资源在任务过程中从无关刺激中脱离。在靶ERP中，N2和P3的潜伏期在Fz、Ct和Pt处线性增加。N2的增加主要是由于N2 b潜伏期在Fz，Ct和Pt处的线性增加，表明与年龄相关的减慢始于非目标/目标刺激的受控记忆比较。P3波幅在中年和老年受试者中呈现更均匀的头皮分布，并且仅在男性中随着年龄的增长而显著降低，这可能解释了文献中关于P3波幅与年龄相关的变化的不同结果。(C)1998 Elsevier Science B. V.保留所有权利。
A total of 73 healthy subjects aged 20-86 years performed an auditory 'oddball' task. The age-dependence of N1 and P2 elicited by non-target stimuli, of N2 and P3 elicited by target stimuli and of N2a and N2b components (target minus non-target difference waves) was investigated across 20 electrodes to detect any aging-related changes in the psychophysiological processing of such stimuli during the task. Aging-related differences in within-task changes in non-target ERPs were also investigated. In non-target ERPs, it was found that P2 amplitude at Fz increased linearly with advancing age and the analysis of within-task changes indicated that P2 amplitude decreased during the task in young subjects at Pt, but remained unchanged in middle-aged and elderly subjects. These results suggest the existence of aging-related inhibitory deficits that may hinder the disengagement of attentional resources from irrelevant stimuli during the task. In the target ERPs, the latencies of N2 and P3 increased linearly at Fz, Ct and Pt. The increases in N2 were mainly due to linear increases in N2b latency at Fz, Ct and Pt, indicating that the aging-related slowing begins at controlled memory comparison of non-target/target stimuli. P3 amplitude presented a more uniform scalp distribution in middle-aged and in elderly subjects and only decreased significantly with advancing age in men, which may explain the divergent results in the literature on aging-related changes of P3 amplitude. (C) 1998 Elsevier Science B.V. All rights reserved.