The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus
The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus
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系统性红斑狼疮循环滤泡辅助性T细胞中Bcl-6的表达与疾病活动度呈正相关
DOI：
10.1016/j.clim.2016.10.017
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发表时间：
2016-12-01
影响因子：
8.6
通讯作者：
Lu, Qianjin
中科院分区：
文献类型：
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作者：
Huang, Xin;Wu, Haijing;Lu, Qianjin
据报道，系统性红斑狼疮 (SLE) 患者的循环滤泡辅助性 T 细胞 (cTfh) 增加。然而，B 细胞淋巴瘤 6 (Bcl-6) 是否在 cTfh 细胞中表达仍有待澄清。在这项研究中，我们发现与健康对照（n = 48）相比，SLE患者（n = 70）中CD4（+）CXCR5（hi）PD-1（hi）cTfh、CD4（+）CXCR5（hi）PD-1（hi）lCOS（hi）和CD4（+）CXCR5（hi）PD-1（hi）Bcl-6（+）群体的频率显着增加。令人惊讶的是，只有CD4（+）CXCR5（hi）PD-1（hi）Bcl-6（+）cTfh细胞，而不是CD4（+）CXCR5（hi）PD-1（hi）群体，与SLEDAI和抗dsDNA抗体呈正相关。 SLE CD4(+) T 细胞中 IL-21 水平升高。此外，IL-21促进Bcl-6启动子区TET2的富集并诱导Bcl-6表达。因此，cTfh 细胞中的 Bcl-6 表达可能代表 SLE 疾病活动性的可靠标志。 (C) 2016 爱思唯尔公司保留所有权利。
Increased circulating follicular helper-like T cells (cTfh) are reported in systemic lupus erythematosus (SLE) patients. However, whether B-cell lymphoma 6 (Bcl-6) is expressed in cTfh cells remains to be clarified. In this study, we found that the frequencies of CD4(+)CXCR5(hi)PD-1(hi)cTfh, CD4(+)CXCR5(hi)PD-1(hi)lCOS(hi), and CD4(+)CXCR5(hi)PD-1(hi)Bcl-6(+) populations were significantly increased in SLE patients (n = 70) when compared with healthy controls (n = 48). Surprisingly, only CD4(+) CXCR5(hi)PD-1(hi)Bcl-6(+) cTfh cells, rather than CD4(+)CXCR5(hi)PD-1(hi) population, were positively correlated with SLEDAI and anti-dsDNA antibodies. An elevated level of IL-21 was found in SLE CD4(+) T cells. Moreover, IL-21 promoted the enrichment of TET2 in Bcl-6 promoter region and induced Bcl-6 expression. Therefore, Bcl-6 expression in cTfh cells may represent a reliable marker for the disease activity in SLE. (C) 2016 Elsevier Inc All rights reserved.