Chronic maternal stress affects growth, behaviour and hypothalamo-pituitary-adrenal function in juvenile offspring
Chronic maternal stress affects growth, behaviour and hypothalamo-pituitary-adrenal function in juvenile offspring
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DOI：
10.1016/j.yhbeh.2008.02.025
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发表时间：
2008-09-01
影响因子：
3.5
通讯作者：
Matthews, Stephen G.
中科院分区：
文献类型：
--
作者：
Emack, Jeff;Kostaki, Alice;Matthews, Stephen G.
怀孕期间的母亲压力，特别是与低社会经济地位（SES）相结合的压力，与儿童行为和情感发育受损和情感障碍的菲斯克增加有关。在动物模型中，产前应激的急性期对下丘脑-垂体-肾上腺（HPA）功能和行为有深远的影响。然而，很少有研究确定长期暴露于压力的动物模型的影响。本研究的目的是确定慢性母体应激（CMS）在怀孕的后半段和护理对幼年豚鼠后代的生长，运动行为和HPA轴功能的影响。怀孕豚鼠暴露于随机组合的变量压力，每隔一天在怀孕的后半期和出生后第1天（pnd），直到断奶（pnd 25）。与对照组母亲相比，CMS母亲在怀孕后期基础唾液皮质醇水平升高（p
Maternal stress during pregnancy, particularly that combined with low socioeconomic status (SES), has been linked to an increased Fisk for impaired behavioural and emotional development and affective disorders in children. In animal models, acute periods of prenatal stress have profound effects on hypothalamo--pituitary-adrenal (HPA) function and behaviour. However, few studies have determined the impact of chronic exposure to stress in animal models. The objective of this study was to determine the effects of chronic maternal stress (CMS) during the 2nd half of pregnancy and nursing on growth, locomotor behaviour and HPA axis function in juvenile guinea pig offspring. Pregnant guinea pigs were exposed to a random combination of variable stressors every other day over the 2nd half of gestation and from postnatal day (pnd) 1 until weaning (pnd25). CMS mothers displayed increased basal salivary cortisol levels in the later stages of pregnancy compared to control mothers (p