Anxiolytic effects of cytotoxic hippocampal lesions in rats
Anxiolytic effects of cytotoxic hippocampal lesions in rats
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DOI：
10.1037//0735-7044.116.3.494
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发表时间：
2002-06-01
影响因子：
1.9
通讯作者：
Rawlins, JNP
中科院分区：
文献类型：
--
作者：
Deacon, RMJ;Bannerman, DM;Rawlins, JNP
海马区细胞毒性损伤的大鼠接受了3项焦虑测试：与一只新大鼠的社交互动。架空的零迷宫(加号迷宫的改进型)。以及食欲不振(在一个陌生的地方吃熟悉的和新的食物)。在社交互动和低食症测试中发现了显著的缓解焦虑的效果，但在零迷宫中没有。这些结果证实并扩展了以前使用传统损伤技术的实验。零迷宫的结果与使用正迷宫的其他实验是一致的，在这些实验中，海马区内给药不能缓解焦虑。尽管行为学测试中的可变性也可能是一个因素。在零迷宫和正迷宫中，由于低食症患者使用的是升高的仪器，所以在零迷宫A中缺乏损伤效应不太可能是由于无法缓解身高引起的焦虑。
Rats with cytotoxic lesions of the hippocampus were given 3 anxiety tests: social interaction with a novel rat. the elevated zero-maze (a modification of the plus-maze). and hyponeophagia (eating familiar and novel foods in a novel place). Marked anxiolytic effects were seen in the social interaction and hyponeophagia tests, but not on the zero-maze. These results confirm and extend previous experiments that used traditional lesion techniques. The zero-maze result was consistent with other experiments using the plus-maze, in which intrahippocampal administrations of pharmacological agents were not anxiolytic. although variability in ethological tests may also be a factor. As the hyponeophagia Lest used an elevated apparatus, as in the zero- and plus-mazes, the lack of a lesion effect in the zero-maze A as unlikely to have been due to an inability to relieve height-induced anxiety.