Evaluation of adherence and factors affecting adherence to combination antiretroviral therapy among White, Hispanic, and Black men in the MACS Cohort.
Evaluation of adherence and factors affecting adherence to combination antiretroviral therapy among White, Hispanic, and Black men in the MACS Cohort.
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DOI：
10.1097/qai.0b013e3181ab6d48
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发表时间：
2009-10-01
期刊：
影响因子：
--
通讯作者：
Detels R
中科院分区：
文献类型：
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作者：
Oh DL;Sarafian F;Silvestre A;Brown T;Jacobson L;Badri S;Detels R
本研究调查了白色、西班牙裔和黑人男性抗逆转录病毒治疗的依从性水平，并分离了与每个种族群体依从性相关的因素。数据收集自2002年4月至2006年10月期间参加多中心艾滋病队列研究（MACS）的1102名男性。自我报告的100%依从性定义为在前四天内服用所有剂量和药丸，报告通常不跳过任何药物，并报告始终遵循药物时间表。与依从性相关的变量通过多水平logistic回归确定每个种族组。还按种族组内的种族分析了依从性。在控制混杂因素后，我们发现西班牙裔和黑人未报告100%依从性的可能性分别是白人的2.16倍和1.37倍（95% CI（1.47，3.18），（1.05，1.79））。来自中美洲、南美洲和加勒比地区的西班牙裔人的依从率较低。来自加勒比地区的黑人的遵守率低于来自其他地区的黑人。
This study investigated levels of adherence to antiretroviral therapy in White, Hispanic and Black men, and isolated factors associated with adherence among each racial group. Data were collected from 1102 men enrolled in the Multicenter AIDS Cohort Study (MACS) followed between April 2002 and October 2006. Self-reported 100% adherence was defined as taking all doses and pills over the previous four-day period, reporting not typically skipping any medications, and reporting always following the medication schedule. Variables associated with adherence were determined by multi-level logistic regression for each racial group. Adherence was also analyzed by ethnicity within racial groups. After controlling for confounders, we found that Hispanics were 2.16 times and Blacks were 1.37 more likely than Whites to not report 100% adherence (95% CI (1.47, 3.18), (1.05, 1.79)). Hispanics with ethnic backgrounds from Central and South America and the Caribbean had lower rates of adherence. Blacks with ethnic backgrounds from the Caribbean had lower rates of adherence than those from other regions.