Pseudomonas-Candida interactions:: An ecological role for virulence factors
Pseudomonas-Candida interactions:: An ecological role for virulence factors
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DOI：
10.1126/science.1070784
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发表时间：
2002-06-21
期刊：
影响因子：
56.9
通讯作者：
Kolter, R
中科院分区：
文献类型：
--
作者：
Hogan, DA;Kolter, R
细菌-真菌的相互作用具有重要的环境、医学和经济意义，但很少在分子水平上得到很好的表征。在这里，我们描述了铜绿假单胞菌和白色念珠菌，两个机会致病菌之间的致病相互作用。铜绿假单胞菌在白色念珠菌上形成致密的生物膜并杀死真菌。相比之下，铜绿假单胞菌既不结合也不杀死酵母菌形式的白色念珠菌。几个铜绿假单胞菌毒力因子在疾病中是重要的，参与杀死白色念珠菌。我们提出，在人类感染背景下研究的许多毒力因素也可能在细菌-真菌相互作用中起作用。
Bacterial-fungal interactions have great environmental, medical, and economic importance, yet few have been well characterized at the molecular level. Here, we describe a pathogenic interaction between Pseudomonas aeruginosa and Candida albicans, two opportunistic pathogens. P. aeruginosa forms a dense biofilm on C. albicans laments and kills the fungus. In contrast, P. aeruginosa neither binds to nor kills yeast-form C. albicans. Several P. aeruginosa virulence factors that are important in disease are involved in the killing of C. albicans laments. We propose that many virulence factors studied in the context of human infection may also have a role in bacterial-fungal interactions.