The effects of adrenocorticotrophic hormone and cortisol on homocysteine and vitamin B concentrations
The effects of adrenocorticotrophic hormone and cortisol on homocysteine and vitamin B concentrations
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DOI：
10.1515/cclm.2006.114
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发表时间：
2006-05-01
影响因子：
6.8
通讯作者：
Arnadottir, Margret
中科院分区：
文献类型：
--
作者：
Berg, Anna L.;Rafnsson, Arnar T.;Arnadottir, Margret
背景：同型半胱氨酸代谢主要受叶酸和维生素 B-12 血清浓度、肾功能和遗传因素的影响。内分泌失调会影响同型半胱氨酸代谢，这也是有据可查的。然而，对下丘脑-垂体-肾上腺轴激素的研究却给出了相互矛盾的结果。方法：将30名健康年轻男性随机分为三组，人数相等；一组接受促肾上腺皮质激素 (ACTH)(1-24) 1 mg 肌注。每天一次，持续 4 天，另一组则接受皮质醇 50 毫克肌肉注射治疗。 t.i.d.观察4天，对照组观察4天。在治疗或观察前后采集空腹血样。结果：ACTH组和皮质醇组的变化模式相同；叶酸（23%和24%）和钴胺素（13%和19%）的血清浓度显着降低，血浆总同型半胱氨酸浓度降低，但未达到显着水平。对照组没有变化。结论：两个治疗组的变化模式几乎相同，表明效果是由皮质醇介导的。叶酸和钴胺血清浓度的降低需要进一步研究。
Background: Homocysteine metabolism is mainly governed by serum concentrations of folate and vitamin B-12, renal function and genetic factors. It is also well documented that endocrinological disturbances influence homocysteine metabolism. However, studies on the hormones of the hypothalamic-pituitary-adrenal axis have given conflicting results.Methods: A total of 30 healthy young males were randomised into three groups of equal size; one group received adrenocorticotrophic hormone (ACTH)(1-24) 1 mg i.m. daily for 4 days, another group was treated with cortisol 50 mg i.m. t.i.d. for 4 days, while a control group was observed for 4 days. Fasting blood samples were collected before and after treatment or observation.Results: The pattern of changes was the same for the ACTH and cortisol groups; there were significant decreases in serum concentrations of folate (23% and 24%) and cobalamines (13% and 19%) and decreases in plasma total homocysteine concentrations that did not reach significance. There were no changes in the control group.Conclusions: The virtually identical pattern of changes in both treatment groups suggests that the effects were mediated by cortisol. The reductions in serum concentrations of folate and cobalamines call for further research.