Molecular Detection of Colorectal Neoplasia
Molecular Detection of Colorectal Neoplasia
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DOI：
10.1053/j.gastro.2010.01.055
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发表时间：
2010-06-01
期刊：
影响因子：
29.4
通讯作者：
Ahlquist, David A.
中科院分区：
文献类型：
--
作者：
Ahlquist, David A.
各种非侵入性的分子方法来筛查结直肠癌正在出现的潜力，以提高筛查的有效性和用户友好性。这些方法是基于对粪便、血液和尿液样本中的分子标记物的灵敏测定。新方法，特别是下一代粪便检测，已被证明可以高准确性地检测结直肠癌和癌前病变。需要在平均风险人群中验证这些技术，以确定其在一般结直肠癌筛查中的作用。本文综述了结直肠癌分子筛查的生物学原理、技术进展、最新临床性能数据和剩余问题。
A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-based tests, have been shown to detect both colorectal cancers and precancerous lesions with high accuracy. Validation of these technologies in average-risk populations are needed to establish their role for general colorectal cancer screening. This review addresses the biological rationale, technical advances, recent clinical performance data, and remaining issues with molecular screening for colorectal cancer.