Contribution of pathogens in human obesity
Contribution of pathogens in human obesity
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DOI：
10.1358/dnp.2004.17.5.829034
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发表时间：
2004-06-01
影响因子：
--
通讯作者：
Dhurandhar, NV
中科院分区：
文献类型：
--
作者：
Dhurandhar, NV
肥胖症在美国和其他国家都在迅速增加。世界卫生组织认为肥胖是一种世界性的流行病，对公共卫生构成重大威胁。在人类中，肥胖引起或加重许多其他疾病和共病。肥胖的病因包括遗传、代谢、社会、行为和文化因素。虽然肥胖有多种原因，但经常被忽视的可能性是由于感染引起的肥胖。在过去的二十年里，有七种病原体被报道会导致动物肥胖。犬瘟热病毒是第一个被报道的促进肥胖的病毒。禽流感相关病毒7是一种禽类逆转录病毒，可导致鸡生长发育迟缓、肥胖和高脂血症。博尔纳病病毒引起大鼠肥胖。据报道，瘙痒症药物可诱导小鼠肥胖。这些病原体似乎通过损害中枢神经系统而产生肥胖。接下来，有三种腺病毒被报道促进肥胖，但它们的机制尚不清楚。动物实验感染SMAM-1，禽腺病毒，或两种人腺病毒，腺病毒36型（Ad-36）和Ad-37，发展肥胖。值得注意的是，SMAM-1和Ad-36与人类肥胖相关。虽然还需要更多的研究来进一步确定致病菌在肥胖病因学中的机制和作用，但它们应该被列入肥胖潜在病因因素的长长名单中。确定病原体在人类肥胖中的作用对于成功治疗和预防肥胖至关重要。(C)2004年，《科学》杂志。All rights reserved.
Obesity is increasing rapidly in the United States as well as in other countries. The World Health Organization considers obesity a worldwide epidemic that poses a major public health threat. In humans, obesity causes or exacerbates a number of other diseases and co-morbidities. Etiology of obesity includes genetic, metabolic, social, behavioral and cultural factors. Although obesity has multiple causes, an often overlooked possibility is that of obesity due to an infection. Over the past two decades, seven pathogens are reported to cause obesity in animals. Canine distemper virus was the first reported obesity-promoting virus. Rous-associated virus-7, an avian retrovirus, causes stunted growth, obesity and hyperlipidemia in chickens. Borna disease virus was noted to cause obesity in rats. Scrapie agents were reported to induce obesity in mice. These pathogens appear to produce obesity by damaging the central nervous system. Next, three adenoviruses were reported to promote obesity, but their mechanisms are not clear. Animals experimentally infected with SMAM-1, an avian adenovirus, or two human adenoviruses, adenovirus type 36 (Ad-36) and Ad-37, developed adiposity. Notably, SMAM-1 and Ad-36 were associated with obesity in humans. Although more research is needed to further define the mechanisms and the role of pathogens in the etiology of obesity, they should be included in the long list of potential etiological factors for obesity. Determination of the role of pathogens in human obesity is critical for its successful treatment and prevention. (C) 2004 Prous Science. All rights reserved.