SPECTRAL-ANALYSIS OF HEART-RATE VARIABILITY IN THE ASSESSMENT OF AUTONOMIC DIABETIC NEUROPATHY
SPECTRAL-ANALYSIS OF HEART-RATE VARIABILITY IN THE ASSESSMENT OF AUTONOMIC DIABETIC NEUROPATHY
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DOI：
10.1016/0165-1838(88)90078-1
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发表时间：
1988-08-01
期刊：
影响因子：
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通讯作者：
MALLIANI, A
中科院分区：
文献类型：
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作者：
PAGANI, M;MALFATTO, G;MALLIANI, A
我们研究了49例无并发症糖尿病患者（27例接受胰岛素治疗，22例接受口服降糖药治疗）和40例年龄匹配的对照组的心率变异性。采用一种自动自回归算法对心电信号的每拍RR变异性进行功率谱密度（PSD）计算。PSD包含两个主要组成部分(一个低频。0.1赫兹（低频）和一个高频，呼吸连接，大约。0.25 Hz (HF))，分别提供交感神经和迷走神经调节活动及其平衡的定量标记。与对照组相比，在糖尿病患者中，除了静止时RR方差降低（2722 +-）。300和1436，+-。我们观察到，在被动倾斜期间，交感神经激活和迷走神经戒断的频谱指数的反应发生了改变，这表明神经控制活动发生了复杂的改变。此外，我们将该方法与常用的临床测试评分进行了比较，发现后者提供的总体结果与倾斜引起的光谱变化相似（r = 0.42; P < 0.01）。具有潜在临床重要性的是，光谱分析获得的数据似乎更彻底地可量化，并且不需要患者的积极合作。
We studied heart rate variability in 49 uncomplicated diabetics (27 with insulin therapy; 22 with oral hypoglycemic agents) and in 40 age-matched controls. An automatic autoregressive algorithm was used to compute the power spectral density (PSD) of beat by beat RR variability derived from the surface ECG. The PSD contains two major components (a low frequency .apprx. 0.1 Hz (LF) and a high frequency, respiratory linked, .apprx. 0.25 Hz (HF)) that provide, respectively, quantitative markers of sympathetic and vagal modulatory activities and of their balance. As compared to controls, in diabetics, besides a reduced RR variance at rest (2722 .+-. 300 and 1436 .+-. 241 ms2, respectively), we observed during passive tilt an altered response of spectral indices of sympathetic activation and vagal withdrawal, suggestive of a complex modification in the neural control activities. In addition, we compared this approach to the commonly used clinical tests score, and observed that the latter provides overall results similar to those obtained with spectral changes induced by tilt (r = 0.42; P < 0.01). Of potential clinical importance is that the data obtained with spectral analysis appear more thoroughly quantifiable and do not require the active collaboration of the patients.