Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age
Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age
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DOI：
10.1016/j.neurobiolaging.2006.04.003
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发表时间：
2007-06-01
影响因子：
4.2
通讯作者：
Andersen, Julie K.
中科院分区：
文献类型：
--
作者：
Kaur, Deepinder;Peng, Jun;Andersen, Julie K.
铁升高在帕金森病中脑中有很好的记录，但其原因和对随后神经变性的贡献仍然未知。在相当于人类生命第一年的发育期内，以相当于铁强化人类婴儿配方奶粉中发现的剂量给予铁的小鼠显示出进行性中脑神经变性和对毒性损伤的脆弱性增强。这可能对新生儿铁摄入量作为帕金森病（PD）后期发展的潜在危险因素的影响产生重大影响。(c)2006年爱思唯尔公司All rights reserved.
Iron elevation is well-documented in the Parkinsonian midbrain but its cause and contribution to subsequent neurodegeneration remain unknown. Mice administered iron at doses equivalent to those found in iron-fortified human infant formula during a developmental period equivalent to the first human year of life display progressive midbrain neurodegeneration and enhanced vulnerability to toxic injury. This may have major implications for the impact of neonatal iron intake as a potential risk factor for later development of Parkinson's disease (PD). (c) 2006 Elsevier Inc. All rights reserved.