Slow and persistent postinhibitory rebound acts as an intrinsic short-term memory mechanism.
Slow and persistent postinhibitory rebound acts as an intrinsic short-term memory mechanism.
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DOI：
10.1523/jneurosci.2998-09.2010
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发表时间：
2010-03-31
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影响因子：
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通讯作者：
Marder E
中科院分区：
文献类型：
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作者：
Goaillard JM;Taylor AL;Pulver SR;Marder E
许多神经元显示抑制后反弹（PIR），其中神经元在抑制后显示增强的兴奋性。PIR可以强烈地影响从抑制性输入反弹的尖峰的时间。我们研究了在外侧幽门（LP）神经元，口胃神经节的一部分，螃蟹癌症borealis。LP神经元是幽门网络的一部分，幽门网络是一种中枢模式发生器，通常以约1 s的周期振荡。我们使用动态箝位在LP神经元中创建各种周期和占空比的人工节律突触输入。令人惊讶的是，我们发现PIR的强度在突触输入的多个周期中缓慢增加。此外，这种增加的兴奋性持续10-20秒后，节奏抑制被删除。这些效应比LP中通常观察到的节律活动慢得多。因此，这种缓慢的抑制后反弹允许神经元在许多周期内将其兴奋性水平调整到抑制的平均水平，这是内在的“短期记忆”机制的另一个例子。
Many neurons display post-inhibitory rebound (PIR), in which neurons display enhanced excitability following inhibition. PIR can strongly influence the timing of spikes on rebound from an inhibitory input. We studied PIR in the Lateral Pyloric (LP) neuron, part of the stomatogastric ganglion of the crab Cancer borealis. The LP neuron is part of the pyloric network, a central pattern generator that normally oscillates with a period of ~ 1 s. We used the dynamic clamp to create artificial rhythmic synaptic inputs of various periods and duty cycles in the LP neuron. Surprisingly, we found that the strength of PIR increased slowly over multiple cycles of synaptic input. Moreover, this increased excitability persisted for 10–20 s after the rhythmic inhibition was removed. These effects are considerably slower than the rhythmic activity typically observed in LP. Thus this slow postinhibitory rebound allows the neuron to adjust its level of excitability to the average level of inhibition over many cycles, and is another example of an intrinsic “short-term memory” mechanism.