Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning
Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning
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DOI：
10.1016/s0006-8993(99)01291-3
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发表时间：
1999-05-08
期刊：
影响因子：
2.9
通讯作者：
Kapp, BS
中科院分区：
文献类型：
--
作者：
Guarraci, FA;Frohardt, RJ;Kapp, BS
杏仁核长期以来一直与条件性恐惧有关。中脑多巴胺能系统为杏仁核提供丰富的神经支配[J.H.Fall，P.Ciofi，《杏仁核内单胺的分布》，见：J.P.Aggleton(编辑)，《杏仁核：情绪、记忆和精神功能障碍的神经生物学方面》，Wiley，New York，1992，第97-114页；L.J.Freedman，M.D.Cassell，《杏仁核中多巴胺能纤维的分布》。脑研究633(1994)243-252；E.阿桑，大鼠杏仁核儿茶酚胺能神经支配。解剖胚胎学与细胞生物学进展142(1996)1-107]。据报道，杏仁系膜多巴胺能系统的特异性激活发生在条件性恐惧唤起刺激的反应中[M.L.Coco，C.M.Kuhn，T.D.Fly，C.D.kitts，选择性激活条件应激对杏仁系膜多巴胺神经元的激活：安定的衰减。大脑研究590(1992)39-47]表明杏仁核中的多巴胺释放可能有助于获得和/或表达条件性恐惧。实验1A采用2×2析因设计，考察了选择性D-1受体拮抗剂SCH 23390(2.0mg0.5mU L(-1)侧(-1))双侧杏仁核内注射对巴甫洛夫条件性恐惧的获得和表达的影响。在获取训练之前、在保持测试之前或在两者之前输入SCH 23390可显著减弱在保持测试期间的条件性冻结。实验1B研究了训练前输注SCH 23390(0.5mg1.0和2.0mg3个剂量)对条件性恐惧的剂量依赖效应。在保留试验期间，训练前输注SCH 23390剂量依赖地减弱条件性冷冻。实验2A观察了选择性D-1受体激动剂SKF 82958(2.0mg0.5mU L(-1)侧(-1))双侧注入对条件性恐惧获得和表达的影响。在训练前输注SKF 82958有助于在保持试验期间进行条件性冷冻。实验2B考察了训练前输注SKF 82958(1.0、2.0和4.0mg)对条件性恐惧的剂量依赖效应。在保留试验期间，训练前输注SKF 82958以剂量依赖的方式促进条件性冷冻。综上所述，这些结果表明，杏仁核内的多巴胺传递有助于巴甫洛夫恐惧条件反射的获得和表达。(C)1999 Elsevier Science B.V.保留所有权利。
The amygdala has long been implicated in conditioned fear. The mesencephalic dopaminergic system provides a rich innervation to the amygdala [J.H. Fallen, P. Ciofi, Distribution of monoamines within the amygdala, in: J.P. Aggleton (Ed.), The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction, Wiley, New York, 1992, pp. 97-114; L.J. Freedman, M.D. Cassell, Distribution of dopaminergic fibers in the central division of the extended amygdala of the rat. Brain Research 633 (1994) 243-252; E. Asan, The catecholaminergic innervation of the rat amygdala. Advances in Anatomy Embryology and Cell Biology 142 (1996) 1-107]. Specific activation of the mesoamygdaloid dopaminergic system has been reported to occur in response to conditioned fear-arousing stimuli [M.L. Coco, C.M. Kuhn, T.D. fly, C.D. Kilts, Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam. Brain Research 590 (1992) 39-47] suggesting that dopamine release in the amygdala may contribute to the acquisition and/or expression of conditioned fear. Using a 2 x 2 factorial design, Experiment 1A investigated the effects of bilateral intra-amygdaloid infusions of the selective D-1 receptor antagonist, SCH 23390 (2.0 mu g 0.5 mu l(-1) side(-1)), on the acquisition and expression of Pavlovian conditioned fear measured by freezing to acoustic and background contextual stimuli. Infusions of SCH 23390 prior to acquisition training, prior to retention testing or prior to both significantly attenuated conditioned freezing during retention testing. Experiment 1B investigated the dose-dependent effects of pre-training infusions of SCH 23390 (0.5, 1.0 and 2.0 mu g) on conditioned fear. Pre-training infusions of SCH 23390 dose-dependently attenuated conditioned freezing during retention testing. Experiment 2A investigated the effects of bilateral infusions of the selective D-1 receptor agonist, SKF 82958 (2.0 mu g 0.5 mu l(-1) side(-1)) on the acquisition and expression of conditioned fear. Infusions of SKF 82958 prior to training facilitated conditioned freezing during retention testing. Experiment 2B investigated the dose-dependent effects of pre-training infusions of SKF 82958 (1.0, 2.0 and 4.0 mu g) on conditioned fear. Pre-training infusions of SKF 82958 dose-dependently facilitated conditioned freezing during retention testing. In conclusion, these results suggest that dopamine transmission within the amygdala contributes to the acquisition and expression of Pavlovian fear conditioning. (C) 1999 Elsevier Science B.V. All rights reserved.