Cockcroft-Gault formula is biased by body weight in diabetic patients with renal impairment
Cockcroft-Gault formula is biased by body weight in diabetic patients with renal impairment
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DOI：
10.1016/j.metabol.2005.07.014
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发表时间：
2006-01-01
影响因子：
9.8
通讯作者：
Gin, H
中科院分区：
文献类型：
--
作者：
Rigalleau, V;Lasseur, C;Gin, H
Cockcroft-Gault (CG) 公式和肾病饮食修改 (MDRD) 方程通常用于估计肾小球滤过率 (GFR)，但它们在极端体重下的有效性值得怀疑。这对于糖尿病患者来说可能意义重大。在 122 名患有肾损伤的糖尿病患者中，我们在根据体重指数 (BMI) 对患者进行分类之前和之后，将这两种估计值与通过相关研究和 Bland 和 Altman 程序确定的同位素 GFR 进行了比较。在整个人群中，CG 高估了 GFR（CG，51.4 +/- 23.1 mL/[min (.) 1.73 m(2)]；同位素 GFR，44.6 +/- 2 1.1 mL/[min (.) 1.73 m(2)]，p
The Cockcroft-Gault (CG) formula and the modification of diet in renal disease (MDRD) equation are commonly used to estimate glomerular filtration rate (GFR), but their validity at extreme body weight is questionable. This may be significant for diabetic patients. In 122 diabetic patients with renal damage, we compared both estimates to isotopically determined GFR by correlation studies and a Bland and Altman procedure before and after categorizing the patients according to body mass index (BMI). Over the whole population, the CG overestimated GFR (CG, 51.4 +/- 23.1 mL/[min (.) 1.73 m(2)]; isotopic GFR, 44.6 +/- 2 1.1 mL/[min (.) 1.73 m(2)], p