Lipid Composition in Different Regions of the Brain in Alzheimer's Disease/Senile Dementia of Alzheimer's Type
Lipid Composition in Different Regions of the Brain in Alzheimer's Disease/Senile Dementia of Alzheimer's Type
复制标题
阿尔茨海默病/阿尔茨海默型老年痴呆大脑不同区域的脂质组成
作者：
Magnus Söderberg;C. Edlund;I. Alafuzoff;K. Kristensson;G. Dallner
摘要：分析了阿尔茨海默病/阿尔茨海默病型老年痴呆患者 10 个不同脑区的脂质组成。尾核和白质中的总磷脂量有所减少。受阿尔茨海默氏病形态影响的皮质区域，即额叶和颞叶皮质以及海马，显示出脂溶剂可提取的磷脂酰肌醇含量升高。富含髓磷脂的区域中鞘磷脂含量降低。大脑所有研究部位的多萜醇含量均减少了 20-50%，但聚异戊二烯模式未见变化。阿尔茨海默病患者大脑中 α-不饱和聚戊二烯的水平降低。大多数地区多油醇磷酸酯含量增加，高达 100%。在对照组织和阿尔茨海默病组织中，几乎所有的多荆基磷酸都是共价结合的，显然是通过糖基化进行的。胆固醇含量变化很大，但大部分没有变化，而受阿尔茨海默病影响的大脑大部分区域的泛醌浓度增加了 30-100%。这些结果表明，在受阿尔茨海默氏病/阿尔茨海默氏型老年性痴呆影响的大脑中，磷脂和中性脂质都发生了改变。
Abstract: The lipid compositions of 10 different brain regions from patients affected by Alzheimer's disease/senile dementia of Alzheimer's type were analyzed. The total phospholipid amount decreased somewhat in nucleus caudatus and in white matter. The cortical areas that are morphologically affected by Alzheimer's disease, i.e., frontal and temporal cortex and the hippocampus, showed elevated contents of lipid solvent‐extractable phosphatidylinositol. Sphingomyelin content was decreased in regions rich in myelin. There was a 20–50% decrease in dolichol amount in all investigated parts of the brain, but no change was seen in the polyisoprenoid pattern. Levels of α‐unsaturated polyprenes were decreased in Alzheimer brains. Dolichyl‐phosphate content increased in most regions, up to 100%. In both control and Alzheimer tissue almost all of the dolichyl‐phosphate was covalently bound, apparently through glycosylation. Cholesterol amounts were highly variable but mostly unchanged, whereas ubiquinone concentrations increased by 30–100% in most regions in brains affected by Alzheimer's disease. These results demonstrate that both phospholipids and neutral lipids are modified in brains affected by Alzheimer's disease/senile dementia of Alzheimer's type.