Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma
Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma
复制标题
乙型肝炎相关肝细胞癌肝切除患者家族史与长期预后的关系
DOI：
10.21037/hbsn.2018.11.20
复制
发表时间：
2019-04-01
影响因子：
8
通讯作者：
Yang, Tian
中科院分区：
文献类型：
--
作者：
Li, Zhen-Li;Han, Jun;Yang, Tian
背景：家族史是肝细胞癌发生的危险因素。本研究的目的是调查2003-2013年间接受根治性肝切除术治疗的乙肝病毒相关性肝癌患者的肝癌家族史与远期肿瘤预后的关系。家族史被定义为一级亲属自我报告的肝细胞癌病史。结果：在1112例患者中，183例(16.5%)有肝细胞癌家族史。使用PSM，179对有和没有家族史的患者在基线特征和手术变量上没有差异。在配对分析中，在倾向配对队列中，家族史与治疗意向切除乙肝相关性肝癌后OS和RFs降低相关(P分别为0.042和0.006)。在多变量COX回归分析中，家族史与OS(HR：1.574；95%CI：1.171~2.116；P=0.003)和RFS(HR：1.534；95%CI：1.176~2.002；P=0.002)相关。
Background: Family history is a risk factor for the development of hepatocellular carcinoma (HCC). The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus (HBV)-related HCC.Methods: Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled. Family history was defined as a self-reported history of HCC in a first-degree relative. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare overall survival (OS) and recurrence-free survival (RFS) among patients with and without a family history.Results: Among 1,112 patients, 183 (16.5%) patients had a family history of HCC. Using PSM, 179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables. On matched analysis, family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort (P=0.042 and 0.006, respectively). On multivariable Cox-regression analyses, a family history of HCC was associated with decreased OS (HR: 1.574; 95% CI: 1.171-2.116; P=0.003) and RFS (HR: 1.534; 95% CI: 1.176-2.002; P=0.002) after adjusting for other prognostic risk factors.Conclusions: Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC.