Assessment of Arterial Arrival Times Derived From Multiple Inversion Time Pulsed Arterial Spin Labeling MRI
Assessment of Arterial Arrival Times Derived From Multiple Inversion Time Pulsed Arterial Spin Labeling MRI
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DOI：
10.1002/mrm.22256
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发表时间：
2010-03-01
影响因子：
3.3
通讯作者：
Jezzard, Peter
中科院分区：
文献类型：
--
作者：
MacIntosh, Bradley J.;Filippini, Nicola;Jezzard, Peter
这项研究的目的是在全脑脉冲动脉自旋标记（PASL）脑灌注MRI中建立正常范围（AAT）。健康的志愿者（n = 36，范围：20至35年）提供了知情同意，以参加这项研究。使用三维梯度和自旋回波（grase）脉冲动脉自旋标记在3.0 t的多个大脑区域中评估AAT，发现为641 +/- 95、804 +/- 91、802 +/- 126，并且分别在颞，顶，额叶和枕叶中的935 +/- 108毫秒。发现女性的平均灰质AAT为694 +/- 89毫秒（n = 15），比男性短得多，814 +/- 192毫秒（n = 21; p <0.0003），校正后有效对于大脑体积（p <0.001）。还使用Voxelwise置换测试发现了显着的AAT性别差异。此处介绍了整个健康大脑中AAT值的地图集，并且对于旨在量化来自ASL数据的脑血流以及疾病病理可能导致AAT改变的临床比较的实验可能很有用。使用相同的抽样方案与经验研究一起模拟脉冲动脉自旋标记信号，并在模拟到达时间远远超出正常范围时可以稳健地估计AAT。 Magn Reson Med 63：641-647，2010。（c）2010 Wiley-Liss，Inc。
The purpose of this study was to establish a normal range for the arterial arrival time (AAT) in whole-brain pulsed arterial spin labeling (PASL) cerebral perfusion MRI. Healthy volunteers (N = 36, range: 20 to 35 years) provided informed consent to participate in this study. AAT was assessed in multiple brain regions, using three-dimensional gradient and spin echo (GRASE) pulsed arterial spin labeling at 3.0 T, and found to be 641 +/- 95, 804 +/- 91, 802 +/- 126, and 935 +/- 108 ms in the temporal, parietal, frontal, and occipital lobes, respectively. Mean gray matter AAT was found to be 694 +/- 89 ms for females (N = 15), which was significantly shorter than for men, 814 +/- 192 ms (N = 21; P < 0.0003), and significant after correcting for brain volume (P < 0.001). Significant AAT sex differences were also found using voxelwise permutation testing. An atlas of AAT values across the healthy brain is presented here and may be useful for future experiments that aim to quantify cerebral blood flow from ASL data, as well as for clinical comparisons where disease pathology may lead to altered AAT. Pulsed arterial spin labeling signals were simulated using an identical sampling scheme as the empiric study and revealed AAT can be estimated robustly when simulated arrival times are well beyond the normal range. Magn Reson Med 63:641-647, 2010. (C) 2010 Wiley-Liss, Inc.