Symptoms of asthma and the home environment. The ISAAC I and III cross-sectional surveys in Munster, Germany
Symptoms of asthma and the home environment. The ISAAC I and III cross-sectional surveys in Munster, Germany
复制标题
DOI：
10.1159/000084613
复制
发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Keil, U
中科院分区：
文献类型：
--
作者：
Behrens, T;Maziak, W;Keil, U
背景：室内家庭环境已被证明与呼吸道症状和特应性疾病的存在有关。方法：使用在德国明斯特收集的 ISAAC I 期和 III 期调查数据进行了两次横断面调查（1995-2000 年）（n=6,996，答复率为 81.8%）。我们分析了 6 至 7 岁儿童的几种室内暴露和哮喘相关结果的患病率 (PR)，并调整了潜在的混杂因素。结果：在接触霉菌、环境烟草烟雾、使用燃气烹饪和使用化石燃料进行空间供暖方面观察到正相关，但大多数关联并不具有统计显着性。令人惊讶的是，地毯的存在与大多数呼吸系统疾病呈负相关。当将分析限制在没有因特应性疾病史而避免地毯的参与者时，保护性关联消失了。大多数情况下，目前养宠物与呼吸道症状没有显示出正相关。然而，生命中不同时期的饲养显示出正相关，特别是对于出生第一年拥有的鸡只（对于喘息引起的睡眠障碍，分别为 PR 1.51，95% CI 1.11-2.06，对于过去 12 个月期间的喘息，分别为 PR 1.28，95% CI 1.01-1.63）。结论：只有少数室内因素与研究结果呈正相关。报告称避免使用地毯与过敏有关的参与者的关联变化表明，观察到的影响是哮喘患者行为改变的结果。与过敏相关的行为变化的影响以及不同年龄段饲养宠物的观察结果强调需要在疾病和暴露之间建立精确的时间关系。版权所有 (C) 2005 S. Karger AG，巴塞尔。
Background: The indoor home environment has been shown to be associated with the presence of respiratory symptoms and atopic disease. Methods: Two cross-sectional surveys (1995-2000) were conducted, using data from the ISAAC phase I and III surveys, collected in Munster, Germany (n=6,996, response 81.8%). We analyzed the prevalence ratio (PR) for several indoor exposures and asthma-related outcomes in 6- to 7-year-old children, adjusting for potential confounders. Results: Positive associations were observed regarding exposure to molds, environmental tobacco smoke, cooking with gas and space heating with fossil fuels, but most associations were not statistically significant. Surprisingly, presence of a carpet was negatively associated with most respiratory conditions. When restricting the analysis to participants without avoidance of a carpet due to a history of atopic disease, the protective associations disappeared. Mostly, present pet ownership did not show positive associations with respiratory symptoms. However, ownership at different times in life revealed positive associations, particularly in regard to birds owned in the first year of life (PR 1.51, 95% CI 1.11-2.06, for sleep disturbance due to wheeze and PR 1.28, 95% CI 1.01-1.63, for wheeze during the last 12 months, respectively). Conclusions: Only few indoor factors were positively associated with the studied outcomes. The change of associations in participants that reported allergy-related avoidance of carpets suggests that the observed effects are a result of asthmatics' changed behavior. The effect of allergy-related change in behavior and the results observed concerning the ownership of pets at different ages underline the need of establishing a precise temporal relationship between disease and exposure. Copyright (C) 2005 S. Karger AG, Basel.