Red cell survival and red cell enzymes in patients on continuous peritoneal dialysis (CAPD).
Red cell survival and red cell enzymes in patients on continuous peritoneal dialysis (CAPD).
复制标题
连续腹膜透析 (CAPD) 患者的红细胞存活率和红细胞酶。
作者：
J. Hefti;A. Blumberg;H. Marti
对11例CAPD伴持续性贫血患者进行了51Cr标记红细胞存活率、红细胞质量和红细胞内几种酶水平的测定。911事件后51Cr红细胞存活时间缩短（平均+/- SD:20.0 +/- 4.9天），且与红细胞数量，即贫血程度相关（r = 0.79, P < 0.01）。单磷酸己糖分流和糖酵解途径的酶水平测定显示红细胞代谢没有明显缺陷。己糖激酶（HK）水平正常，葡萄糖-6-磷酸脱氢酶（G-6-PD）、6-磷酸葡萄糖酸脱氢酶（6-PGD）、谷胱甘肽还原酶（GR）、丙酮酸激酶（PK）及还原性谷胱甘肽（GSH）活性显著升高。CAPD并没有消除大多数患者贫血的溶血成分。
In 11 patients on CAPD with persisting anemia the survival of red cells labelled with 51Cr, red cell mass and the levels of several enzymes within red cells were measured. 51Cr red cell survival was shortened in 9/11 (mean +/- SD:20.0 +/- 4.9 days) and correlated with red cell mass, i.e. with the degree of anemia (r = 0.79, P less than 0.01). Determinations of the levels of enzymes of the hexose monophosphate shunt and the glycolytic pathway revealed no obvious defects in red cell metabolism. The level of hexokinase (HK) was normal whereas the activities of glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR) and pyruvate kinase (PK) as well as reduced glutathione (GSH) were increased significantly. CAPD did not eliminate the hemolytic component of anemia in the majority of these patients.