Interaction between serum neutrophil gelatinase associated lipocalin and visceral fat area on cardiovascular health in a cohort of community-based individuals
Interaction between serum neutrophil gelatinase associated lipocalin and visceral fat area on cardiovascular health in a cohort of community-based individuals
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DOI：
10.1016/j.cca.2023.117606
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发表时间：
2023-10-27
影响因子：
5
通讯作者：
Ma，Xiaojing
中科院分区：
文献类型：
--
作者：
Hu，Tingting;Xu，Yiting;Ma，Xiaojing
背景：我们评估了中性粒细胞明胶酶相关脂钙蛋白（NGAL）、脂肪分布及其对社区中老年人群主要不良心血管事件（MACE）发生的相互作用的预测价值。方法本前瞻性研究纳入2013-2014年来自社区的1349名成年人（43.2%为男性），年龄50-80岁，无基线心血管疾病。通过电话和医疗记录对所有参与者进行了平均7.6年的随访。在基线时分析血清NGAL浓度。通过磁共振成像评估脂肪分布，包括皮下脂肪区和内脏脂肪区（VFA）。结果在全校正Cox回归模型中，与低NGAL浓度相比，基线高NGAL浓度与女性MACE风险增加相关[HR 1.75, 95% CI 1.03-2.99]。在按VFA浓度分层后，观察到的相关性在基线低VFA的女性中更为突出（HR 1.24, 95% CI 1.11-1.38）。此外，NGAL与MACE之间存在VFA的相互作用，在低VFA浓度下，NGAL与MACE之间的相互作用增强（p < 0.05）。结论基线时血清NGAL水平可预测MACE的发展，VFA可改变这种相关性。
BackgroundWe assessed the predictive values of neutrophil gelatinase-associated lipocalin (NGAL), fat distribution, and their interaction on the development of major adverse cardiovascular events (MACE) in a community-based cohort of middle-aged and older individuals.MethodsThis prospective study involved 1349 adults (43.2% men) aged 50–80 y, without baseline cardiovascular diseases, from communities in 2013–2014. All participants were followed up for a mean of 7.6 y via phone calls and medical records. Serum NGAL concentrations were analyzed at baseline. Fat distribution, including subcutaneous fat area and visceral fat area (VFA), was assessed by magnetic resonance imaging.ResultsIn fully-adjusted Cox regression models, baseline high NGAL concentrations were related to an increased risk of MACE in women [HR 1.75, 95% CI 1.03–2.99], compared with low NGAL concentrations. After stratification by VFA concentrations, the observed association was more predominant in women with baseline low VFA (HR 1.24, 95% CI 1.11–1.38). Moreover, the association between NGAL and MACE was interacted by VFA, strengthening the association at low VFA concentrations (Pinteraction< 0.05).ConclusionsSerum NGAL determined at baseline predicts the development of MACE, and the association is modified by VFA in women.