Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome
Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome
复制标题
DOI：
10.1038/sj.npp.1301005
复制
发表时间：
2006-08-01
影响因子：
7.6
通讯作者：
Reeves, William C.
中科院分区：
文献类型：
--
作者：
Capuron, Lucile;Welberg, Leonie;Reeves, William C.
慢性疲劳综合征（CFS）患者经常抱怨认知功能障碍。然而，在一些研究中发现了CFS患者认知功能障碍的证据，而不是其他研究。这种异质性的结果可能源于相对存在的精神疲劳的患者人群检查。本研究在CFS患者的人群样本中评估了这种可能性。总共有43例CFS患者，采用2003年国际CFS研究小组推荐的测量方法，根据1994年研究病例定义的标准定义，53例年龄、性别和种族/民族匹配的非疲劳受试者被纳入研究。精神疲劳采用多维疲劳量表的精神疲劳分量表进行评估。使用自动化成套计算机化测试（剑桥神经心理测试自动化成套测试（CANTAB））评估认知功能，该测试评估心理功能、计划和解决问题的能力以及记忆和注意力表现。CFS患者的精神疲劳的投诉显着（精神疲劳的分数2个标准差以上的非疲劳受试者的平均值）表现出显着的损害，在空间工作记忆和持续的注意力（快速视觉信息处理）的任务相比，CFS患者的精神疲劳和非疲劳的投诉低。在CFS患者的显着精神疲劳，持续的注意力表现受损，只有在最后阶段的测试，表明更大的认知疲劳在这些患者。CFS患者低精神疲劳显示性能相比，nonfatigued科目的所有测试的CANTAB电池。这些研究结果表明，CFS患者的心理疲劳的主观投诉和认知功能障碍的客观测量之间的高度一致性，并表明，心理疲劳是CFS相关的认知功能障碍的重要组成部分。
Patients with chronic fatigue syndrome (CFS) frequently complain of cognitive dysfunction. However, evidence of cognitive impairment in CFS patients has been found in some, but not other, studies. This heterogeneity in findings may stem from the relative presence of mental fatigue in the patient populations examined. The present study assessed this possibility in a population-based sample of CFS patients. In all, 43 patients with CFS defined by the criteria of the 1994 research case definition using measurements recommended by the 2003 International CFS Study Croup, and 53 age-, sex-, and race/ethnicity-matched nonfatigued subjects were included in the study. Mental fatigue was assessed using the mental fatigue subscale of the multidimensional fatigue inventory. Cognitive function was evaluated using an automated battery of computerized tests (Cambridge neuropsychological test automated battery (CANTAB)) that assessed psychomotor function, planning and problem-solving abilities, and memory and attentional performance. CFS patients with significant complaints of mental fatigue (score of mental fatigue 2 standard deviations above the mean of nonfatigued subjects) exhibited significant impairment in the spatial working memory and sustained attention (rapid visual information processing) tasks when compared to CFS patients with low complaints of mental fatigue and nonfatigued subjects. In CFS patients with significant mental fatigue, sustained attention performance was impaired only in the final stages of the test, indicating greater cognitive fatigability in these patients. CFS patients with low mental fatigue displayed performance comparable to nonfatigued subjects on all tests of the CANTAB battery. These findings show strong concordance between subjective complaints of mental fatigue and objective measurement of cognitive impairment in CFS patients and suggest that mental fatigue is an important component of CFS-related cognitive dysfunction.