Prevalence and clinical correlates of tic disorders in a community sample of school-age children
Prevalence and clinical correlates of tic disorders in a community sample of school-age children
复制标题
DOI：
10.1007/s00787-011-0223-z
复制
发表时间：
2012-01-01
影响因子：
6.4
通讯作者：
Scahill, Lawrence
中科院分区：
文献类型：
--
作者：
Kraft, Janne Tabori;Dalsgaard, Soren;Scahill, Lawrence
研究社区样本中确定的抽动儿童的患病率、临床特征和病程。这是一项三阶段研究。1990年1月至1992年4月期间，在奥胡斯大学医院Skejby出生的8，244名9至11岁儿童的父母被邀请完成有关抽搐的筛查问卷。一年后，参与的父母完成了优势和困难问卷（SDQ）。从2004年12月到2005年6月，当队列年龄为13-15岁时，对抽搐筛查阳性儿童的父母进行了详细的抽动障碍访谈。抽动秽语综合征（TS）的患病率为0.6%，慢性运动性抽搐（CMT）的患病率为0.6%。大约三分之一的慢性抽动障碍[CTD（TS和CMT）]患者在13-15岁时报告抽动缓解。在父母评定的SDQ中，患有CTD的儿童的可能性是（OR = 5.0，95% CI = 2.6-9.2）落入多动临床范围的可能性为2倍（OR = 2.2，95% CI = 2.1-7.5）表现出破坏性和挑衅性行为，情绪困难的可能性增加4倍以上（OR = 4.7，95%CI = 2.5-8.6）。多动和CTD的儿童比单纯CTD的受试者受损更严重。CTD和多动儿童在多个行为领域和整体损害中表现出更严重的症状。在没有多动症的情况下，患有CTD的儿童出现情绪困难的风险会增加，但不会出现破坏性行为问题。
To examine the prevalence, clinical characteristics and course of children with tics identified in a community sample. This was a three-stage study. At the age of 9 to 11, parents of 8,244 children born at Aarhus University Hospital Skejby between January 1990 and April 1992 were invited to complete a screening questionnaire about tics. One year later participating parents completed the Strengths and Difficulties Questionnaire (SDQ). From December 2004 to June 2005, when the cohort was 13-15 years of age, parents of the children who screened positive for tics were interviewed in detail about tic disorders. The prevalence of Tourette Syndrome (TS) was 0.6 and 0.6% of chronic motor tics (CMT). Approximately one-third of those with a chronic tic disorder [CTD (TS and CMT)] reported remission of tics by age 13-15. On the parent-rated SDQ children with a CTD were five times more likely (OR = 5.0, 95% CI = 2.6-9.2) to fall into the clinical range of hyperactivity, twice as likely (OR = 2.2, 95% CI = 2.1-7.5) to exhibit disruptive and defiant behavior and over four times more likely to have emotional difficulties (OR = 4.7, 95% CI = 2.5-8.6) compared to children without tic disorders. Children with hyperactivity and CTD were more impaired than subjects with CTD only. Children with CTD and hyperactivity show greater symptom severity across several domains of behavior and overall impairment. In the absence of hyperactivity, children with CTD are at increased risk for emotional difficulties, but not disruptive behavior problems.