Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure
Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure
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I 型胶原代谢的生物标志物与心力衰竭时的 B 型利钠肽、左心室大小和舒张功能相关
DOI：
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发表时间：
2014
影响因子：
3
通讯作者：
H. Persson
中科院分区：
文献类型：
--
作者：
Johan Löfsjögård;T. Kahan;J. Díez;B. López;Arantxa González;M. Edner;P. Henriksson;M. Mejhert;H. Persson
目的通过循环生物标志物间接评价心肌胶原代谢。我们的目的是研究心力衰竭患者心肌I型胶原合成和降解与超声心动图、临床和B型利钠肽（BNP）结果之间的关系。方法我们研究了57名女性和75名男性60岁或以上收缩性心力衰竭（纽约心脏协会II-IV级和射血分数≥ 45%）。平均年龄为75岁，血压为134/80 mmHg，射血分数为34%，中位BNP为210 ng/l。 测定I型前胶原羧基末端前肽（PICP，I型胶原合成的生物标志物）和I型胶原血清羧基末端端肽（CITP，I型胶原降解的生物标志物）的分析。进行了广泛的超声心动图检查，包括不同步的变量。结果胶原合成增加（PICP）与BNP水平升高独立相关（r = 0.24，P = 0.018）。 此外，PICP与左心室大小、等容舒张时间和相对室壁厚度之间存在独立相关性。胶原降解增加（CITP）与BNP水平升高独立相关（r = 0.35，P <0.001）。 此外，CITP与E/E'间隔和QRS持续时间之间存在单变量而非多变量相关性。结论收缩性心力衰竭患者I型胶原合成和降解的生物标志物与BNP、左室大小和舒张功能指标独立相关。它建议，BNP可能有助于在收缩性心力衰竭的I型胶原代谢的改变。
Aims Myocardial collagen metabolism can be assessed indirectly by circulating biomarkers. We aimed to examine associations between myocardial collagen type I synthesis and degradation, and echocardiographic, clinical, and B-type natriuretic peptide (BNP) findings in heart failure. Methods We studied 57 women and 75 men 60 years or older with systolic heart failure (New York Heart Association II–IV and an ejection fraction ⩽45%). Mean age was 75 years, blood pressure 134/80 mmHg, ejection fraction 34%, and median BNP 210 ng/l. Analyses of the carboxy-terminal propeptide of procollagen type I (PICP, biomarker of collagen type I synthesis) and the serum carboxy-terminal telopeptide of collagen type I (CITP, biomarker of collagen type I degradation) were measured. Extensive echocardiographic examinations were performed, including variables of dyssynchrony. Results Increased collagen synthesis (PICP) was independently related to increased BNP levels (r = 0.24, P = 0.018). Furthermore, independent associations were found between PICP and left ventricular size, isovolumic relaxation time, and relative wall thickness. Increased collagen degradation (CITP) was independently related to increased BNP levels (r = 0.35, P < 0.001). Also, univariable, but not multivariable, associations were found between CITP and E/E’ septal and QRS duration. Conclusion Biomarkers of collagen type I synthesis and degradation are independently related to BNP and to indices of left ventricular size and diastolic function in systolic heart failure. It is proposed that BNP may contribute to alterations in collagen type I metabolism in systolic heart failure.
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影响因子：
120.7
作者：
Redfield, MM;Jacobsen, SJ;Rodeheffer, RJ
通讯作者：
Rodeheffer, RJ
影响因子：
120.7
作者：
Bursi, Francesca;Weston, Susan A.;Roger, Veronique L.
通讯作者：
Roger, Veronique L.
影响因子：
8.3
作者：
CAO, L;GARDNER, DG
通讯作者：
GARDNER, DG
影响因子：
37.8
作者：
BELTRAMI, CA;FINATO, N;ANVERSA, P
通讯作者：
ANVERSA, P
利尿钠肽治疗心血管疾病的新治疗方向：即将到来。
影响因子：
2.5
作者：
BurnettJr,JohnC
通讯作者：
BurnettJr,JohnC