CROSS-CORRELATION ANALYSIS OF THE MAINTAINED DISCHARGE OF RABBIT RETINAL GANGLION-CELLS
CROSS-CORRELATION ANALYSIS OF THE MAINTAINED DISCHARGE OF RABBIT RETINAL GANGLION-CELLS
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DOI：
10.1113/jphysiol.1981.sp013812
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发表时间：
1981-01-01
影响因子：
5.5
通讯作者：
SPRAKER, TE
中科院分区：
文献类型：
--
作者：
ARNETT, D;SPRAKER, TE
同时对兔视网膜神经节细胞进行记录。利用生理测试对每个细胞的感受野特性进行分类，并绘制感受野位置图。同时记录的视网膜神经节细胞之间的统计依赖性是通过交叉相关同时记录的细胞维持放电来评估的。在组成细胞没有重叠的感受野中心的细胞对中，相互关系在统计上是平坦的，反映了没有统计依赖性。大多数由短暂和持续同心细胞组成的细胞对，具有重叠的感受野中心，表现出相关的维持放电，表明统计依赖性。统计依赖性的强度与组成细胞对的两个细胞之间的重叠程度近似成反比。由2个on中心细胞或2个off中心细胞组成的细胞对具有重叠的感受野中心，具有递增的相互关系，其特征是中心接近零的峰值。由一个on中心细胞和一个off中心细胞组成的细胞对具有重叠的感受野中心，具有以接近零为中心的谷为特征的递减相互关联。结果与假设一致，即噪声源为2个或更多的视网膜神经节细胞提供共享输入。双极和光感受器是视网膜神经节细胞之间统计依赖性的最可能的噪声来源。
Simultaneous recordings were made from pairs of rabbit retinal ganglion cells. Physiological tests were used to classify the receptive field properties of each cell, and the receptive field locations were mapped. The statistical dependence between simultaneously recorded retinal ganglion cells was assessed by cross-correlating the maintained discharge of the simultaneously recorded cells. Cross-correlations from cell pairs in which the constituent cells had non-overlapping receptive field centers were statistically flat, reflecting no statistical dependence. Most cell pairs consisting of transient and sustained concentric cells and having overlapping receptive field centers exhibited a correlated maintained discharge indicative of statistical dependence. The strength of the statistical dependence varied approximately inversely with the degree of overlap between the two cells comprising the cell pair. Cell pairs consisting of 2 ON-center cells or 2 OFF-center cells and having overlapping receptive field centers possessed incremental cross-correlations which were characterized by a peak centered near zero. Cell pairs consisting of an ON-center cell with an OFF-center cell and having overlapping receptive field centers possessed decremental cross-correlations characterized by a valley centered near zero. Results are consistent with the hypothesis that a noise source provides shared input to 2 or more retinal ganglion cells. Bipolar and photoreceptors are the most likely sources of noise responsible for the statistical dependency between retinal ganglion cells.