CHANGES IN BONE SODIUM AND CARBONATE IN METABOLIC ACIDOSIS AND ALKALOSIS IN DOG
CHANGES IN BONE SODIUM AND CARBONATE IN METABOLIC ACIDOSIS AND ALKALOSIS IN DOG
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DOI：
10.1172/jci106499
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发表时间：
1971-01-01
影响因子：
15.9
通讯作者：
BURNELL, JM
中科院分区：
文献类型：
--
作者：
BURNELL, JM
成年犬的代谢性酸中毒和碱中毒在5至10天的时间内发生。分析胫骨中皮质骨钙、钠、磷和碳酸盐含量。酸中毒时骨CO3/Ca下降9.5%，骨Na/Ca下降6.3%。碱中毒组骨CO3/Ca升高3.1%，骨Na/Ca升高3.0%。以前试图通过细胞外和细胞内酸碱变化的总和来解释净酸平衡的变化，结果一致表明，大约40-60%的酸的获得或损失是“无法解释的”。如果假设胫骨皮质的变化反映了整个骨骼系统的变化，那么骨骼CO3=的变化足够大，可以解释“未解释的”酸变化，而无需假设细胞代谢酸产生的变化。
Metabolic acidosis and alkalosis were produced in adult dogs over 5- to 10-day periods. Midtibial cortical bone was analyzed for calcium, sodium, phosphorus, and carbonate. In acidosis bone CO3/Ca decreased 9.5% and bone Na/Ca decreased 6.3%. In alkalosis bone CO3/Ca increased 3.1% and bone Na/Ca increased 3.0%.Previous attempts to account for changes in net acid balance by summation of extra- and intracellular acid-base changes have uniformly resulted in about 40-60% of acid gained or lost being “unaccounted for.” If it is assumed that changes in tibial cortex reflect changes in the entire skeletal system, changes in bone CO3=are sufficiently large to account for the “unaccounted for” acid change without postulating changes in cellular metabolic acid production.