Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation
Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation
复制标题
DOI：
10.1016/j.supflu.2013.08.014
复制
发表时间：
2013-11-01
影响因子：
3.9
通讯作者：
Goto, Motonobu
中科院分区：
文献类型：
--
作者：
Nerome, Hazuki;Machmudah, Siti;Goto, Motonobu
为了提高番茄红素在水中的分散性，采用超临界流体溶液增强分散（SEDS）技术研究了番茄红素与β-环糊精包合物的沉淀过程。以N，N-二甲基甲酰胺（DMF）为溶剂制备包合物，将其溶解于同一溶剂中，然后以二氧化碳（CO2）为超临界抗溶剂，采用SEDS进行微粉化。研究了番茄红素和β-环糊精的初始浓度、CO2流速、溶液流速以及进行该过程的压力和温度的影响。通过扫描电子显微镜（SEM）和场发射扫描电子显微镜（FE-SEM）观察所得颗粒的形貌。在所有操作条件下均获得小球形颗粒。在高压、高温、高CO2流量和低溶液流量下，获得平均粒径约为40 nm的颗粒。(C)2013爱思唯尔有限公司版权所有。
With a view to promoting dispersion of lycopene in water, the precipitation of an inclusion complex of lycopene and beta-cyclodextrin was investigated using the solution-enhanced dispersion by supercritical fluids (SEDS) process. The inclusion complex, which was prepared in N,N-dimethylformamide (DMF), was dissolved in the same solvent and then micronized by SEDS, using carbon dioxide (CO2) as a supercritical antisolvent. The effects of the initial concentrations of lycopene and beta-cyclodextrin, the CO2 flow rate, the solution flow rate, and the pressure and temperature at which the process was conducted were examined. The morphologies of the resulting particles were observed by scanning electron microscopy (SEM) and field emission-scanning electron microscopy (FE-SEM). Small spherical particles were obtained at all operating conditions. At high pressure, high temperature, high CO2 flow rate and low solution flow rate, particles with an average particle size of about 40 nm were obtained. (C) 2013 Elsevier B.V. All rights reserved.