An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits.
An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits.
复制标题
抗肿瘤坏死因子抗体可抑制大鼠和兔子的睡眠。
DOI：
10.1016/0006-8993(95)00609-t
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Krueger,JM
中科院分区：
文献类型：
--
作者：
Takahashi,S;Kapás,L;Fang,J;Krueger,JM
It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 μg TNFab did not affect sleep but decreased brain temperature; in contrast, 25 μg TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.
