Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests.
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests.
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DOI：
10.18632/aging.202307
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发表时间：
2020-12-22
期刊：
影响因子：
--
通讯作者：
Bonomi M
中科院分区：
文献类型：
--
作者：
Cangiano B;Fatti LM;Danesi L;Gazzano G;Croci M;Vitale G;Gilardini L;Bonadonna S;Chiodini I;Caparello CF;Conti A;Persani L;Stramba-Badiale M;Bonomi M
引言：COVID-19大流行导致养老院的死亡率上升，原因是其快速传播和与年龄相关的高致死率。结果：我们观察到两个月的死亡率为40%，而前一年为6.4%。在COVID-19阳性（43%）和阴性（24%）居民中均观察到这种增加，但在拭子检测阴性的患者中，有8名患者在血清学检测中呈阳性。死亡率增加与男性、年龄较大、既往未补充维生素D和日常生活活动（ADL）评分较差（如Barthel指数、Tinetti量表和S.OS.I.A.）相关。分类.结论：我们的数据证实了COVID-19导致的老年死亡率较高。阴性居民也有较高的死亡率，我们怀疑这是次要的分析前的错误和低灵敏度的拭子测试在依从性差的受试者。男性、年龄较大和ADL量表评分较低（可能是由于不动）是COVID-19相关死亡率的风险因素。最后，死亡率与维生素D补充呈负相关。设计图：在这项观察性研究中，我们描述了SARS-CoV-2传播后疗养院157名居民（年龄60-100岁）的两个月死亡率，报告了与结果相关的因素。我们还比较了SARS-CoV-2的诊断测试。
Introduction: The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread and the age-related high lethality. Results: We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increase was seen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among those testing negative on the swab, tested positive on serological tests. Increased mortality was associated with male gender, older age, no previous vitamin D supplementation and worse “activities of daily living (ADL)” scores, such as Barthel index, Tinetti scale and S.OS.I.A. classification. Conclusion: Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had higher mortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorly compliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) are risk factors for COVID-19 related mortality. Finally, mortality was inversely associated with vitamin D supplementation. Design: In this observational study, we described the two-month mortality among the 157 residents (age 60-100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. We also compared the diagnostic tests for Sars-CoV-2.
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影响因子：
6.1
作者：
Liu, Kui;Fang, Yuan-Yuan;Liu, Hui-Guo
通讯作者：
Liu, Hui-Guo
影响因子：
6.3
作者：
通讯作者：
--
影响因子：
9.3
作者：
Viecca, Maurizio;Radovanovic, Dejan;Santus, Pierachille
通讯作者：
Santus, Pierachille
DOI：
10.1111/jth.14817
发表时间：
2020-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
通讯作者：
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DOI：
10.1016/j.jsbmb.2020.105771
发表时间：
2020-11
期刊：
The Journal of steroid biochemistry and molecular biology
影响因子：
--
作者：
Annweiler C;Hanotte B;Grandin de l'Eprevier C;Sabatier JM;Lafaie L;Célarier T
通讯作者：
Célarier T