Folate intake and the primary prevention of non-neural birth defects
Folate intake and the primary prevention of non-neural birth defects
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DOI：
10.1111/j.1467-842x.2006.tb00867.x
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发表时间：
2006-06-01
影响因子：
3.5
通讯作者：
Serna, Peta
中科院分区：
文献类型：
--
作者：
Bower, Carol;Miller, Margaret;Serna, Peta
目的：研究西澳大利亚州孕妇围孕期叶酸摄入量是否与选择性非神经性出生缺陷减少有关。方法：对患有口面裂（62例）、先天性心脏缺陷（151例）、泌尿道缺陷（1117例）、肢体缩小缺陷（26例）或其他主要出生缺陷（119例）的孕妇进行叶酸摄入量的病例对照研究。结果：无论是叶酸补充剂，也不是膳食中的叶酸摄入量的妇女不使用补充剂是显着相关的风险降低，在任何情况下组。相反，神经管缺陷，西澳人口的口面裂，心脏缺陷，肢体减少缺陷和尿路缺陷的数据显示，自引入叶酸促进和自愿food fortifulment.Conclusions：这项研究提供了没有证据表明叶酸是一个重要的因素，在预防出生缺陷以外的神经管缺陷。
Objectives: To investigate whether maternal periconceptional folate intake is associated with a reduction in selected non-neural birth defects in Western Australia (WA).Methods: Case-control study of folate intake in women whose infants had orofacial clefts (62); congenital heart defects (151); urinary tract defects (1117); limb reduction defects (26); or other major birth defects (119); and 578 control women.Results: Neither folic acid supplements nor dietary folate intake in women not using supplements was significantly associated with a reduction in risk in any of the case groups. In contrast to neural tube defects, WA population data for orofacial clefts, heart defects, limb reduction defects and urinary tract defects showed no fall in prevalence since the introduction of folate promotion and voluntary food fortification.Conclusions: This study provides no evidence of folate being an important factor in the prevention of birth defects other than neural tube defects.