CORNEAL EPITHELIAL CHANGES IN DIABETIC RATS
CORNEAL EPITHELIAL CHANGES IN DIABETIC RATS
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DOI：
10.1159/000265202
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发表时间：
1982-01-01
影响因子：
2.1
通讯作者：
THOFT, RA
中科院分区：
文献类型：
--
作者：
FRIEND, J;ISHII, Y;THOFT, RA
电镜观察显示糖尿病大鼠眼内张力原丝和糖原含量增加，上皮下基底膜增厚、内翻，基底细胞变性。糖原，葡萄糖，山梨糖醇和果糖测定角膜上皮细胞从短期和长期糖尿病大鼠。在8个月后发现山梨醇途径产物的小幅增加。的糖尿病（< 1.0 mOsmoles/1组织水）证实了在兔子和人类中的类似发现。在山梨醇途径产物无显著蓄积的情况下发生形态学变化。继发于角膜上皮细胞山梨醇蓄积的渗透性损害可能不是角膜上皮糖尿病的重要因素。
EM of streptozotocin diabetic rat eyes showed increased intracellular levels of tonofilaments and glycogen, thickenings and infoldings of subepithelial basement membrane and basal cell degeneration after 8 mo. Glycogen, glucose, sorbitol and fructose were measured in corneal epithelium from short- and long-term diabetic rats. The small increase in sorbitol pathway products which were found after 8 mo. of diabetes (< 1.0 mOsmoles/1 tissue water) confirmed similar findings in rabbits and humans. The morphologic changes occur in the absence of significant accumulation of sorbitol pathway products. Osmotic damage secondary to corneal epithelial cell accumulation of sorbitol is probably not a significant factor in corneal epithelial diabetic disease.