Universal ocular screening of 481 infants using wide-field digital imaging system.
Universal ocular screening of 481 infants using wide-field digital imaging system.
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DOI：
10.1186/s12886-018-0943-7
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发表时间：
2018-10-30
影响因子：
2
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Ma Y;Deng G;Ma J;Liu J;Li S;Lu H
在中国儿童卫生保健系统中，普遍的婴儿眼部筛查并不是一个标准程序。本初步研究利用宽视场数字成像系统调查6周龄婴儿眼部异常的患病率。于2015年4月至2016年8月在某公立医院连续入组6周左右的婴儿。所有入组婴儿均采用手电、检眼镜、宽视场数字成像系统进行视力评估、眼位检查、外眼检查、瞳孔光反射、红色反射检查、前、后眼段检查。481名出生后45.1±6.1天的婴儿被纳入研究。异常患儿198例（41.2%）。视网膜白斑和视网膜白色区域是最常见的发现（42.9%的异常和17.7%的所有筛查婴儿）。第二个主要发现是视网膜出血(16.2%的异常和6.7%的所有筛查婴儿)。其他异常表现包括视网膜色素沉着、伴发性外斜视、新生儿泪囊炎、早产儿视网膜病变、“白化病样眼底”、先天性鼻泪管阻塞、家族性渗出性玻璃体视网膜病变、未成熟视网膜、角膜皮样肿瘤、视盘大生理性拔罐、先天性持续性瞳孔膜、内翻倒、结膜下出血、先天性白内障、玻璃体出血、上睑下垂和脉络膜痣。22名婴儿需要任何形式的干预，占检测到的异常的11.1%，占所有筛查婴儿的4.6%。普遍的眼部筛查不仅对早产儿是必要的，而且对足月婴儿也是必要的。加用广角数字成像系统进行红色反射检查，可提高眼底异常筛查的灵敏度。需要进一步的长期随访研究。
Universal ocular screening of infants is not a standard procedure in children’s health care system in China. This pilot study investigated prevalence of ocular abnormalities of 6 weeks-age infants using wide-field digital imaging system. Infants aged 6 weeks around were consecutively enrolled in a public hospital between April 2015 and August 2016. All the infants who were enrolled in the study underwent vision assessment, eye position examination, external eye check, pupillary light reflex, red reflex examination, anterior and posterior ocular segments were examined using flashlight, ophthalmoscope, and wide-field digital imaging system. A total of 481 infants at 45.1 ± 6.1 days after birth were enrolled in the study. 198 infants had abnormal findings (41.2%). Retinal white spots and retinal white areas were the most common findings (42.9% of abnormalities and 17.7% of all infants screened). The second major finding was retinal hemorrhage (16.2% of abnormalities and 6.7% of all infants screened). Other abnormal findings include retinal pigmentation, concomitant exotropia, neonatal dacryocystitis, retinopathy of prematurity, ‘albinism-like fundus’, congenital nasolacrimal duct obstruction, familial exudative vitreoretinopathy, immature retina, corneal dermoid tumor, large physiologic cupping of optic disc, congenital persistent pupillary membrane, entropion trichiasis, subconjunctival hemorrhage, congenital cataract, vitreous hemorrhage, ptosis and choroidal nevus. Intervention of any form was required in 22 infants, which accounted for 11.1% of abnormalities detected and 4.6% of all infants screened. Universal ocular screening is not only necessary for preterm infants but also for full-term infants. Addition of red reflex examination with wide-field digital imaging system can enhance the sensitivity of screening for ocular fundus abnormities. Further study with a long-term follow-up is needed in the future.
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影响因子：
13.7
作者：
Pendergast, SD;Trese, MT
通讯作者：
Trese, MT
影响因子：
4.1
作者：
ELSTON, JS;TIMMS, C
通讯作者：
TIMMS, C
影响因子：
13.7
作者：
Callaway NF;Ludwig CA;Blumenkranz MS;Jones JM;Fredrick DR;Moshfeghi DM
通讯作者：
Moshfeghi DM
DOI：
10.3928/01913913-20141028-01
发表时间：
2015-01-01
影响因子：
1.2
作者：
Dotan, Gad;Nelson, Leonard B.
通讯作者：
Nelson, Leonard B.
影响因子：
--
作者：
Petersen, David B.;Chandler, Danielle L.;Vaswani, Reena S.
通讯作者：
Vaswani, Reena S.