Response in chronic schizophrenia correlated with chlorpromazine, 7-OH-chlorpromazine and chlorpromazine sulfoxide levels
Response in chronic schizophrenia correlated with chlorpromazine, 7-OH-chlorpromazine and chlorpromazine sulfoxide levels
复制标题
慢性精神分裂症的反应与氯丙嗪、7-OH-氯丙嗪和氯丙嗪亚砜水平相关
DOI：
10.1016/0924-977x(95)00047-s
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发表时间：
1996
影响因子：
5.6
通讯作者：
R. Miller
中科院分区：
文献类型：
--
作者：
M. Chetty;V. Pillay;S. Moodley;R. Miller
本研究探讨了氯丙嗪及其六种代谢产物与慢性精神分裂症疗效的关系。Logistic回归分析显示，治疗反应与四种代谢产物，即Nor 1氯丙嗪，Nor 2氯丙嗪，氯丙嗪-N-氧化物和Nor，氯丙嗪亚砜之间无相关性。CPZ（P = 0.036）、7-羟基氯丙嗪（P = 0.004）、氯丙嗪亚砜（P = 0.002）与治疗反应之间存在良好的相关性。良好的治疗反应与高水平的氯丙嗪及其7-羟基代谢物相关，而高水平的亚砜代谢物似乎对治疗反应有负面影响。氯丙嗪水平高的不良反应者也有高水平的亚砜代谢物。这表明反应的差异可能在于药物代谢的差异。
The relationship between chlorpromazine, six of its metabolites and therapeutic response in chronic schizophrenic patients was investigated in this study. Logistic regression revealed no correlation between therapeutic response and four metabolites viz. Nor1chlorpromazine, Nor2chlorpromazine, chlorpromazine-N-oxide and Nor, chlorpromazine sulfoxide. A good correlation was seen between CPZ (P = 0.036), 7-hydroxychlorpromazine (P = 0.004), chlorpromazine sulfoxide (P = 0.002) and therapeutic response. Good therapeutic response was correlated to high levels of chlorpromazine and its 7-hydroxy metabolite while high levels of the sulfoxide metabolite appeared to have a negative effect on therapeutic response. Poor responders who had high levels of chlorpromazine also had high levels of the sulfoxide metabolite. This suggests that the difference in response may lie in the difference in the metabolism of the drug.
精神抑制药剂量和血浆水平在精神病药物治疗中的意义。
影响因子：
--
作者：
Baldessarini,RJ;Cohen,BM;Teicher,MH
通讯作者：
Teicher,MH