The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China.
The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China.
复制标题
可切除胃癌患者淋巴血管侵犯的预后意义：来自中国南方的大型回顾性研究。
DOI：
10.1186/s12885-015-1370-2
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发表时间：
2015-05-07
期刊：
影响因子：
3.8
通讯作者：
Cai MY
中科院分区：
文献类型：
--
作者：
Li P;He HQ;Zhu CM;Ling YH;Hu WM;Zhang XK;Luo RZ;Yun JP;Xie D;Li YF;Cai MY
本研究的重点是评估淋巴血管侵犯（LVI）对中国可切除胃癌（GC）患者癌症复发和长期生存的影响。回顾性分析1148例胃癌患者行胃切除术合并局部淋巴结切除术的临床病理资料。主要目的是评估每位患者LVI与术后预后之间的相关性。通过常规h&e染色检测LVI对患者无病生存期（DFS）和疾病特异性生存期（DSS）的影响。1148例GC患者中404例（35.2%）检出LVI。LVI的存在与CA19-9水平、肿瘤大小、Lauren分型、肿瘤分化、胃壁浸润深度、淋巴结累及、远处转移、TNM分期等相关。与无LVI患者相比，LVI患者的DFS和DSS较低。多变量分析也确定LVI是DSS和DFS的独立预后因素。LVI的存在是癌症复发的危险因素，也是胃癌患者术后预后不良的独立指标。在确定治疗个体的最佳方法时，应考虑到LVI状态。
The focus of this study was to assess the impact of lymphovascular invasion (LVI) on both the recurrence of cancer and the long-term survival of Chinese patients with resectable gastric cancer (GC). A retrospective analysis of the clinicopathological data for 1148 GC patients who had undergone gastrectomy with regional lymphadenectomy was performed. The primary objective was to assess the correlation between LVI and post-surgery outcomes for each patient. This was done by routine H & E staining for LVI on patients’ disease-free survival (DFS) and disease-specific survival (DSS). LVI was detected in 404 (35.2%) of the 1148 GC patients. The presence of LVI was significantly correlated with the level of CA19-9, the tumor size, the Lauren classification, tumor differentiation, gastric wall invasive depth, lymph node involvement, distant metastasis and an advanced TNM stage. There was a lower DFS and DSS in the patients with LVI as compared to the patients without LVI. A multivariate analysis also identified LVI as an independent prognostic factor of both DSS and DFS. The presence of LVI is a risk factor for the recurrence of cancer and an independent indicator of a poor outcome in GC patients following surgery. The LVI status should be taken into consideration when determining the best approach for the treatment of the individual.
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影响因子：
4.3
作者：
Gresta, Leticia Trivellato;Rodrigues-Junior, Ismael Alves;Demas Alvares Cabral, Monica Maria
通讯作者：
Demas Alvares Cabral, Monica Maria
影响因子：
6.6
作者：
Pichler, Martin;Hutterer, Georg C.;Zigeuner, Richard
通讯作者：
Zigeuner, Richard
影响因子：
4.3
作者：
Du, Chun-Yan;Chen, Jing-Gui;Shi, Ying-Qiang
通讯作者：
Shi, Ying-Qiang
DOI：
10.1007/s00432-007-0264-3
发表时间：
2008-02-01
影响因子：
3.6
作者：
del Casar, Jose M.;Corte, Maria D.;Vizoso, Francisco J.
通讯作者：
Vizoso, Francisco J.
影响因子：
2.2
作者：
Kim, Jong-Han;Park, Sung-Soo;Kim, Young-Sik
通讯作者：
Kim, Young-Sik