Catalytic asymmetric [3 3] annulation of cyclopropanes with mercaptoacetaldehyde
Catalytic asymmetric [3 3] annulation of cyclopropanes with mercaptoacetaldehyde
复制标题
环丙烷与巯基乙醛的催化不对称[3 3]环化
DOI：
10.1039/c6ob00948d
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Feng Xiaoming
中科院分区：
文献类型：
--
作者：
Fu Xuan;Lin Lili;Xia Yong;Zhou Pengfei;Liu Xiaohua;Feng Xiaoming
A highly diastereo- and enantioselective [3 + 3] annulation of donor–acceptor cyclopropanes with mercaptoacetaldehyde has been developed. In the presence of a N,N′-dioxide–Sc(III) complex as the catalyst, a number of aromatic substituted cyclopropyl ketones reacted with mercaptoacetaldehyde smoothly, providing the corresponding chiral tetrahydrothiopyranols in moderate yields with excellent ee (up to 99% ee) and dr values (up to >19 : 1).
