CHRONIC EPSTEIN-BARR VIRUS-INFECTION ASSOCIATED WITH FEVER AND INTERSTITIAL PNEUMONITIS - CLINICAL AND SEROLOGIC FEATURES AND RESPONSE TO ANTIVIRAL CHEMOTHERAPY
CHRONIC EPSTEIN-BARR VIRUS-INFECTION ASSOCIATED WITH FEVER AND INTERSTITIAL PNEUMONITIS - CLINICAL AND SEROLOGIC FEATURES AND RESPONSE TO ANTIVIRAL CHEMOTHERAPY
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DOI：
10.7326/0003-4819-104-5-636
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发表时间：
1986-05-01
影响因子：
39.2
通讯作者：
RUBIN, RH
中科院分区：
文献类型：
--
作者：
SCHOOLEY, RT;CAREY, RW;RUBIN, RH
两名患者出现发热、间质性肺炎和全血细胞减少症，并伴有EB病毒复制抗原抗体的极高滴度。与大多数Epstein-Barr病毒血清阳性患者相反，两名患者均未对Epstein-Barr核抗原K多肽产生抗体应答。此外，从一名患者中分离的病毒在基因组的EcoRI C区域中具有B 95 -8型的缺失。EB病毒复制和这种综合征的临床表现之间的病因学关系进一步显示了每个患者对阿昔洛韦治疗的反应。这些患者有一个新的EB病毒相关综合征，并提供了额外的证据表明，阿昔洛韦可能在治疗选定的EB病毒感染患者的作用。
Two patients developed fever, interstitial pneumonitis, and pancytopenia associated with extremely high titers of antibody to replicative antigens of the Epstein-Barr virus. In contrast to most patients seropositive for Epstein-Barr virus, neither patient had an antibody response to the Epstein-Barr nuclear antigen K polypeptide. In addition, virus isolated from one patient had a deletion of the B95-8 type in the EcoRI C region of the genome. An etiologic relation between Epstein-Barr virus replication and the clinical manifestations of this syndrome is further shown by the response of each patient to acyclovir therapy. These patients have a new Epstein-Barr-virus-associated syndrome and provide additional evidence that acyclovir may play a role in therapy for selected patients with Epstein-Barr virus infection.