Immediate and long-term plasticity in human somatosensory thalamus and its involvement in phantom limbs.
Immediate and long-term plasticity in human somatosensory thalamus and its involvement in phantom limbs.
复制标题
人类体感丘脑的即时和长期可塑性及其与幻肢的关系。
DOI：
10.1016/s0304-3959(99)00136-0
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发表时间：
1999
期刊：
影响因子：
7.4
通讯作者：
Dostrovsky,JonathanO
中科院分区：
文献类型：
--
作者：
Dostrovsky,JonathanO
本文描述了作者在70年代中期与帕特里克·沃尔进行的可塑性研究，然后回顾了最近在作者的实验室进行的人体相关研究。人类研究表明，丘脑神经元经常有阈值下感受野(RF)，在RF可逆地阻断传入活动后，一些神经元立即对其正常RF以外的部位的触觉刺激产生更高的敏感性。还描述和讨论了截肢患者的新发现。结果表明，近端肢体的代表扩大到丘脑区域，该区域过去代表被截肢的部分。此外，在那些有幻肢的患者中，该区域的微刺激产生了被认为起源于幻肢的感觉。
This paper describes studies on plasticity that the author undertook with Patrick Wall in the mid'70s, and then reviews recent related studies in humans carried out in the author's laboratory. The human studies have shown that thalamic neurons frequently have subliminal receptive fields (RFs) and immediately following a reversible block of afferent activity from the RF some neurons develop increased sensitivity to tactile stimulation at sites outside their normal RF. Also described and discussed are novel findings in patients that had a limb amputated. The results suggested an expansion of the representation of the proximal limb into the thalamic region that used to represent the amputated part. Furthermore, in those patients that had a phantom limb, microstimulation in this region induced sensations perceived as originating on the phantom.