Effects of CPAP therapy on subcutaneous adipose tissue in patients with obstructive sleep apnea: a meta-analysis
Effects of CPAP therapy on subcutaneous adipose tissue in patients with obstructive sleep apnea: a meta-analysis
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CPAP 治疗对阻塞性睡眠呼吸暂停患者皮下脂肪组织的影响：荟萃分析
DOI：
10.1007/s11325-020-02051-y
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发表时间：
2020-04
影响因子：
2.5
通讯作者：
Qichang Lin
中科院分区：
文献类型：
--
作者：
Qingshi Chen;Guofu Lin;Jianming Zhao;Shuyi Zhang;Ningfang Lian;Jiefeng Huang;Qichang Lin
持续气道正压通气（CPAP）是治疗阻塞性睡眠呼吸暂停（OSA）的有效方法。然而，关于CPAP对OSA患者皮下脂肪组织（SAT）的影响，研究提供了相互矛盾的结果。因此，我们进行了一项荟萃分析，以评估CPAP是否对OSA患者的SAT有影响。通过检索科克伦图书馆、Web of Science、Embase和Pubmed检索研究。提取关于研究和患者特征、研究设计以及CPAP治疗前后SAT的信息进行分析。并对不同的SAT测定方法进行了说明。采用标准化均数差（SMD）和95%可信区间（CI）估计CPAP治疗前后SAT的变化。使用RevMan v.5.3和Stata 14.0进行荟萃分析。共有10项研究符合纳入标准，最终分析中包含309例患者。汇总估计值显示，CPAP治疗未导致SAT发生显著变化（SMD =-0.014，95% CI =-0.161至0.133，p = 0.896）。荟萃回归分析显示，没有预测因素，包括测量SAT的方法，影响CPAP对SAT的影响。我们的荟萃分析表明，CPAP治疗后，OSA患者的SAT无显著变化。
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA). However, studies provide conflicting results on the effects of CPAP on subcutaneous adipose tissue (SAT) in patients with OSA. We therefore performed a meta-analysis to evaluate whether or not CPAP has an effect on SAT in patients with OSA. Studies were retrieved by searching the Cochrane Library, Web of Science, Embase, and Pubmed. Information on study and patient characteristics, study design, and SAT pre- and post-CPAP treatment was extracted for analysis. Different methods for measurement of SAT were also notated. Standardized mean difference (SMD) and 95% confidence interval (CI) were measured to estimate the change in SAT before and after CPAP treatment. Meta-analysis was performed using the RevMan v.5.3 and Stata 14.0. A total of 10 studies met inclusion criteria encompassing 309 patients in the final analysis. The pooled estimate showed that CPAP treatment resulted in no significant change in SAT (SMD = − 0.014, 95% CI = − 0.161 to 0.133, p = 0.896). Meta-regression analyses revealed no predictor, including methods of measuring SAT, that influenced the CPAP effect on SAT. Our meta-analysis demonstrated that after CPAP therapy, there was no significant change in SAT in patients with OSA.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
0.6
作者：
D. Moher;A. Liberati;J. Tetzlaff;D. Altman
通讯作者：
D. Moher;A. Liberati;J. Tetzlaff;D. Altman
影响因子：
--
作者：
Babu, AR;Herdegen, J;Mazzone, T
通讯作者：
Mazzone, T
DOI：
10.1164/rccm.201209-1688oc
发表时间：
2013-07-15
影响因子：
24.7
作者：
Drager, Luciano F.;Yao, Qiaoling;Polotsky, Vsevolod Y.
通讯作者：
Polotsky, Vsevolod Y.