Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy
Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy
复制标题
DOI：
10.1016/j.biomaterials.2008.08.036
复制
发表时间：
2008-12-01
期刊：
影响因子：
14
通讯作者：
Bellamkonda, Ravi V.
中科院分区：
文献类型：
--
作者：
Karathanasis, Efstathios;Chan, Leslie;Bellamkonda, Ravi V.
纳米级治疗干预在癌症治疗组合中越来越重要。纳米治疗剂的功效部分取决于它们通过渗漏的肿瘤脉管系统进入肿瘤的途径。然而，个体肿瘤中肿瘤血管渗漏的程度变化很大，导致相应的宽肿瘤闭合和对治疗的反应范围。在这里，我们报告了一种多功能纳米载体的设计，该多功能纳米载体同时封装化疗剂和造影剂，其通过允许通过乳房X线摄影术（一种广泛使用的成像方式）跟踪纳米载体分布来实现用于乳腺癌治疗的个性化纳米治疗方法。在大鼠乳腺肿瘤模型中全身给药后，成像显示纳米载体在肿瘤内有广泛的沉积，表明肿瘤血管渗漏程度不同。值得注意的是，通过成像显示出纳米载体的高摄取的特定肿瘤正是对治疗反应最好的动物，如通过低肿瘤生长和延长的存活来量化的。(c)2008爱思唯尔有限公司保留所有权利。
Nanoscale therapeutic interventions are increasingly important elements in the portfolio of cancer therapeutics. The efficacy of nanotherapeutics is dictated, in part, by the access they have to tumors via the leaky tumor vasculature. Yet, the extent of tumor vessel leakiness in individual tumors varies widely resulting in a correspondingly wide tumor closing and resulting range of responses to therapy. Here we report the design of a multifunctional nanocarrier that simultaneously encapsulates a chemotherapeutic and a contrast agent which enables a personalized nanotherapeutic approach for breast cancer therapy by permitting tracking of the nanocarrier distribution by mammography, a widely used imaging modality. Following systemic administration in a rat breast tumor model, imaging demonstrated a wide range of intratumoral deposition of the nanocarriers, indicating variable tumor vessel leakiness. Notably, specific tumors that exhibited high uptake of the nanocarrier as visualized by imaging were precisely the animals that responded best to the treatment as quantified by low tumor growth and prolonged survival. (c) 2008 Elsevier Ltd. All rights reserved.