Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?
Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?
复制标题
DOI：
10.1097/jes.0b013e3181b7b7c5
复制
发表时间：
2009-10
影响因子：
5.7
通讯作者：
Funai K
中科院分区：
文献类型：
--
作者：
Cartee GD;Funai K
160 kDa 的 Akt 底物（称为 AS160 或 TBC1D4）和 TBC1D1（调节葡萄糖转运的 Rab GTP 酶激活蛋白）会因运动或胰岛素刺激而磷酸化。有证据表明，这种融合可能是不完美的，每次刺激都会产生独特的磷酸信号，为它们在运动和胰岛素刺激的葡萄糖转运中明显独特且重叠的作用提供了一个合理的机制。
Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase activating proteins that regulate glucose transport, become phosphorylated with exercise- or insulin-stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phospho-signature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport.