Predicting children's quality of life in an asthma clinical trial: What do children's reports tell us?
Predicting children's quality of life in an asthma clinical trial: What do children's reports tell us?
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DOI：
10.1067/mpd.2001.119444
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发表时间：
2001-12-01
影响因子：
5.1
通讯作者：
Lincoln, A
中科院分区：
文献类型：
--
作者：
Annett, RD;Bender, BG;Lincoln, A
Objective: To define predictors of disease-specific quality of life (QOL) and the relationship between asthma symptoms and disease-specific QOL.Study design: Three hundred thirty-nine children participated at 4 of 8 Childhood Asthma Management Program clinical centers. Included in the analyses were 2 weeks of asthma symptom data, child-reported health status, and QOL scores from the Pediatric Asthma Quality of Life Questionnaire. Data were obtained 12 months after randomization into the Childhood Asthma Management Program.Results: Children were rated at baseline as having "moderate" asthma (63%) and "mild" asthma (37%). QOL scores were correlated with the child-reported anxiety measures. Factor analysis of the QOL measure resulted in 2 factors. Stepwise multiple regression indicated that the strongest independent predictors of QOL were the child's anxiety level, age, sex, and a measure of the childs tendency to minimize or exaggerate symptoms.Conclusions: Children had few asthma symptoms in the 2 weeks before their 12-month Follow-up clinic Visit and a generally positive QOL, suggesting that mild-to-moderate asthma does not significantly impair QOL. A child's QOL was predicted primarily by their level of anxiety.
