pKa values in organic chemistry - Making maximum use of the available data
pKa values in organic chemistry - Making maximum use of the available data
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DOI：
10.1016/j.tetlet.2018.08.054
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发表时间：
2018-10-17
影响因子：
1.8
通讯作者：
Leito, Ivo
中科院分区：
文献类型：
--
作者：
Kutt, Agnes;Selberg, Sigrid;Leito, Ivo
酸和碱无处不在。有时，必须了解要使用的酸/碱的准确强度（pK(a) 值），但有时只需酸度/碱度顺序就足够了。我们经常收到测量不同物质在不同溶剂中的 pK(a) 值的请求，以回答“什么酸可以用来质子化这种物质”或“什么碱可以使该化合物去质子化？”等问题。事实上，这些问题通常可以使用已发表的不同溶剂中的 pK(a) 数据来回答。本摘要/教程将概述如何有效利用现有的 pK(a) 数据。 (C) 2018 Elsevier Ltd. 保留所有权利。
Acids and bases are ubiquitous. Sometimes, it is essential to know the accurate strength (pK(a) values) of the acids/bases to work with, but sometimes just acidity/basicity order is enough. We often receive, requests to measure pK(a) values of different substances in different solvents for answering questioris like "what acids can be used to protonate this substance" or "what base is able to deprotonate, that compound?" Such questions can, in fact, often be answered using published pK(a) data in different solvents. This digest/tutorial will give an overview of how to make efficient use of the existing pK(a) data. (C) 2018 Elsevier Ltd. All rights reserved.