Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens.
Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens.
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DOI：
10.3389/fmicb.2018.00843
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发表时间：
2018
影响因子：
5.2
通讯作者：
Knowles SCL
中科院分区：
文献类型：
--
作者：
Leung JM;Graham AL;Knowles SCL
脊椎动物的肠道中充满了大量的、多样的和动态的细菌群落，其对肠道生理、代谢和免疫具有广泛的影响。在自然条件下，这些微生物与类似的动态真核生物群落（蠕虫，原生动物和真菌）共享栖息地，其中许多是众所周知的寄生虫。寄生虫和原核微生物群都可以显著改变肠道的物理和免疫景观，为它们相互作用创造充足的机会。这种相互作用可能会严重改变感染结果，并影响宿主的整体健康和疾病。例如，寄生虫感染可以改变宿主与其细菌植物群相互作用的方式，从而驱动或保护免受生态失调和炎性疾病的影响。相反，微生物群可以改变寄生虫的定殖成功率、复制和毒力，使其沿着寄生-互利共生谱沿着移动。这些相互作用的机制和后果刚刚开始在微生物学和寄生虫学边界的新兴跨学科领域得到阐明。然而，异质性的实验设计，宿主和寄生虫物种，以及主要是现象学和分类学的方法来综合文献，这意味着跨研究的共同主题仍然难以捉摸。在这里，我们使用生态学的角度来回顾文献中的原核微生物和真核寄生虫在脊椎动物肠道之间的相互作用。利用有关寄生虫生物学和生态学的知识，我们讨论了它们可能与肠道微生物相互作用的机制，这种相互作用对宿主健康的后果，以及如何理解寄生虫-微生物群相互作用可能导致疾病控制的新方法。
The vertebrate gut teems with a large, diverse, and dynamic bacterial community that has pervasive effects on gut physiology, metabolism, and immunity. Under natural conditions, these microbes share their habitat with a similarly dynamic community of eukaryotes (helminths, protozoa, and fungi), many of which are well-known parasites. Both parasites and the prokaryotic microbiota can dramatically alter the physical and immune landscape of the gut, creating ample opportunities for them to interact. Such interactions may critically alter infection outcomes and affect overall host health and disease. For instance, parasite infection can change how a host interacts with its bacterial flora, either driving or protecting against dysbiosis and inflammatory disease. Conversely, the microbiota can alter a parasite's colonization success, replication, and virulence, shifting it along the parasitism-mutualism spectrum. The mechanisms and consequences of these interactions are just starting to be elucidated in an emergent transdisciplinary area at the boundary of microbiology and parasitology. However, heterogeneity in experimental designs, host and parasite species, and a largely phenomenological and taxonomic approach to synthesizing the literature have meant that common themes across studies remain elusive. Here, we use an ecological perspective to review the literature on interactions between the prokaryotic microbiota and eukaryotic parasites in the vertebrate gut. Using knowledge about parasite biology and ecology, we discuss mechanisms by which they may interact with gut microbes, the consequences of such interactions for host health, and how understanding parasite-microbiota interactions may lead to novel approaches in disease control.
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影响因子：
3.1
作者：
Burgess, Stacey L.;Saleh, Mahmoud;Petri, William A., Jr.
通讯作者：
Petri, William A., Jr.
影响因子：
30.3
作者：
Benson A;Pifer R;Behrendt CL;Hooper LV;Yarovinsky F
通讯作者：
Yarovinsky F
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
15.9
作者：
Bartelt, Luther A.;Roche, James;Guerrant, Richard
通讯作者：
Guerrant, Richard
影响因子：
--
作者：
Basualdo, J.;Sparo, M.;Minvielle, M.
通讯作者：
Minvielle, M.