DIETARY RESTRICTION INCREASES INSULIN SENSITIVITY AND LOWERS BLOOD-GLUCOSE IN RHESUS-MONKEYS
DIETARY RESTRICTION INCREASES INSULIN SENSITIVITY AND LOWERS BLOOD-GLUCOSE IN RHESUS-MONKEYS
复制标题
DOI：
10.1152/ajpendo.1994.266.4.e540
复制
发表时间：
1994-04-01
影响因子：
--
通讯作者：
BERGMAN, RN
中科院分区：
文献类型：
--
作者：
KEMNITZ, JW;ROECKER, EB;BERGMAN, RN
胰岛素敏感性和葡萄糖耐量通常在晚年下降。在一项关于成年期开始的饮食限制对衰老过程的影响的多维随机试验中，我们使用改进的最小模型方法纵向研究了对照组（C，n = 15，随意喂食规定的饮食6-8小时/天）和限制组（R，n = 15，喂食比C少30%）猴子的胰岛素敏感性和葡萄糖调节。计算个体动物在30个月饲料处理期间的线性变化率，并在处理组之间进行比较。基础葡萄糖、基础胰岛素和胰岛素对葡萄糖和甲苯磺丁脲的反应在C组增加，在R组减少（P小于或等于0.002），而胰岛素敏感性在C组减少，在R组增加（P = 0.008）。30个月时，R组糖化血红蛋白略低（P = 0.06），与空腹血糖呈正相关（r = 0.508，P < 0.001）。胰岛素的变化与肥胖（体重和腹围）的变化显著相关。确定这些作用的实现机制可能有助于改善老年人的葡萄糖耐受不良、胰岛素抵抗和相关疾病。
Insulin sensitivity and glucose tolerance typically decline during later life. In a multidimensional randomized trial of the effects of dietary restriction started in adulthood on the processes of aging, we are studying insulin sensitivity and glucoregulation longitudinally in control (C, n = 15, fed a defined diet ad libitum for 6-8 h/day) and restricted (R, n = 15, fed 30% less than C) monkeys using the Modified Minimal Model method. Linear rates of change were calculated for individual animals through 30 mo of diet treatment and compared between treatment groups. Basal glucose, basal insulin, and insulin responses to glucose and tolbutamide increased for C and decreased for R animals (P less than or equal to 0.002), whereas insulin sensitivity decreased for C and increased for R (P = 0.008). Glycosylated hemoglobin at 30 mo was marginally lower in R (P = 0.06) and was positively correlated with fasting plasma glucose (r = 0.508, P < 0.001). Insulin changes were significantly correlated with changes in adiposity (weight and abdominal circumference). Identification of the mechanisms through which these effects are achieved may aid in ameliorating glucose intolerance, insulin resistance, and associated illnesses in older persons.