Advances in imaging angiogenesis and inflammation in atherosclerosis.
Advances in imaging angiogenesis and inflammation in atherosclerosis.
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DOI：
10.1160/th10-08-0562
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发表时间：
2011-05
影响因子：
6.7
通讯作者：
Mulligan-Kehoe MJ
中科院分区：
文献类型：
--
作者：
Zagorchev L;Mulligan-Kehoe MJ
成像技术的进步为解剖动脉粥样硬化的血管生成和炎症方面提供了强有力的工具。改进的技术沿着多模态方法已经扩大了成像的利用。最近的进展提供了更好地定义血管生成血管的结构和发育、鉴定炎性介质和血管壁之间的关系、验证抗炎和抗血管生成药物的生物学效应、递送和/或靶向特定分子至动脉粥样硬化斑块的炎性区域的能力。
Advances in imaging technology have provided powerful tools for dissecting the angiogenic and inflammatory aspects of atherosclerosis. Improved technology along with multi-modal approaches has expanded the utilisation of imaging. Recent advances provide the ability to better define structure and development of angiogenic vessels, identify relationships between inflammatory mediators and the vessel wall, validate biological effects of anti-inflammatory and anti-angiogenic drugs, delivery and/or targeting specific molecules to inflammatory regions of atherosclerotic plaques.