Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.
Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.
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浸润性乳腺癌中的血管生成和基质纤连蛋白表达。
DOI：
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发表时间：
1998
影响因子：
5.2
通讯作者：
Y. Morishita
中科院分区：
文献类型：
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作者：
H. Takei;Y. Iino;J. Horiguchi;M. Maemura;Y. Koibuchi;H. Nagaoka;T. Yokoe;T. Oyama;Y. Morishita
用免疫组织化学方法分析了83例乳腺癌标本中血管生成和基质纤维连接蛋白（SFN）的表达。与淋巴结转移、TNM分期、复发和死亡率相关的微血管计数（MVC）在sfn阳性肿瘤中相对较低。SFN的表达与淋巴结转移或肿瘤大小无关。然而，SFN阳性在复发患者中的可能性低于无复发患者，SFN阳性肿瘤患者的无复发生存期明显优于SFN阴性肿瘤患者。MVC和SFN阳性是无复发生存、肿瘤大小和腋窝淋巴结状态的重要独立预测因子（Cox比例风险回归分析）。血管生成和SFN表达呈负相关，可用于乳腺癌患者的预后。
Angiogenesis and stromal fibronectin (SFN) expression were immunohistochemically analyzed in 83 breast cancer specimens. Microvessel count (MVC), which correlated with lymph node metastasis, TNM stage, recurrence, and mortality, was relatively low in SFN-positive tumors. SFN expression did not correlate with lymph node metastases or tumor size. However, SFN positivity was less likely in patients with recurrent disease than in those without recurrence, and relapse-free survival was significantly better in patients with SFN-positive tumors than in those with SFN-negative tumors. MVC and SFN positivity were significant independent predictors of relapse-free survival as well as tumor size and axillary nodal status (Cox's proportional hazards regression analysis). Angiogenesis and SFN expression, both of which are inversely related, can be used prognostically in patients with breast cancer.